| Project/Area Number |
15K18536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University (2016-2017)
Institute of Physical and Chemical Research (2015) |
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Principal Investigator |
Umetsu Daiki 東北大学, 生命科学研究科, 助教 (60620474)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | コンパートメント境界 / 組織構築 / 自己組織化 / 細胞の選り分け / 細胞間認識 / ショウジョウバエ / トランスクリプトーム解析 |
|---|
| Outline of Final Research Achievements |
The formation of straight compartment boundaries separating groups of cells is an evolutionarily conserved strategy for tissue growth and patterning during multicellular organism development. In this project, I aimed to reveal the mechanisms that underlie this phenomenon by considering as a fundamental process important for tissue organization by cellular self-organization. By using a recently developed genome editing technology, I found that a molecule, whose vertebrate homologues function in immune cells to recognize non-self molecules, plays an important role in maintaining compartment boundaries in a Drosophila epithelial tissue.
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