| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In the present study, we aimed to elucidate 1) how the Denisovan-like (archaic-like) haplotype related to high-altitude adaptation in Tibetan highlanders has been introduced into modern humans and 2) the association of EGLN1 genetic polymorphisms related to high-altitude adaptation with physiological responses in lowlanders with lowlander ancestry. The Denisovan-like haplotype was not detected from Melanesian populations with 4-6% of their genetic material from Denisovans, suggesting that archaic-like EPAS1 genetic variants have expanded in Tibetan highlanders after the divergence from other ethnic groups. In addition, genetic variants of two polymorphic sites around the EGLN1 gene were associated with arterial oxygen saturation (SpO2) levels and the reaction time (SpO2 latency) in Japanese lowlanders.
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