Physiological polytypism of hemodynamics in highlanders - comparison between Tibetan, Andean and Japanese people-

• Project/Area Number: 15K18623
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied anthropology
• Research Institution: Nagasaki University
• Principal Investigator: NISHIMURA Takayuki 長崎大学, 医歯薬学総合研究科(医学系), 助教 (80713148)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 高地適応 / 生理的多型 / 生理人類学 / 生理的多型性

Outline of Final Research Achievements

Homo sapience who settled in the highlands adapted the circulation function to hypobaric hypoxia for maintain the oxygen level in the whole body. However, there is little discussion about physiological variation within highland groups and rerated factors. Therefore, we investigated the modern highland group. In results, both Andean and Tibetan populations have physiological variation and such variation thought to be influenced by genetic and living environment factors.

Research Products

• [Int'l Joint Research] サン・アンドレアス大学(ボリビア)
• [Int'l Joint Research] サン・アンドレアス大学(ボリビア)
• [Journal Article] Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans (2017)
  • Author(s): Nishimura Takayuki、Katsumura Takafumi、Motoi Midori、Oota Hiroki、Watanuki Shigeki
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 5570-5570
  • DOI: 10.1038/s41598-017-05766-3
  • NAID: 120006987436
  • Peer Reviewed / Open Access
• [Journal Article] Effect of repeated forearm muscle cooling on the adaptation of skeletal muscle metabolism in humans (2017)
  • Author(s): Hitoshi Wakabayashi, Takayuki Nishimura, Titis Wijayanto, Shigeki Watanuki, Yutaka Tochihara
  • Journal Title: International Journal of Biometeorology Volume: 61 Issue: 7 Pages: 1261-1267
  • DOI: 10.1007/s00484-016-1303-z
  • NAID: 120006484238
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Relationship between mitochondrial haplogroup and physiological responses to hypobaric hypoxia (2016)
  • Author(s): Motoi M, Nishimura T, Egashira Y, Kishida F, Watanuki S
  • Journal Title: J Physiol Anthropol Volume: 35 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s40101-016-0094-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Seasonal variation of non-shivering thermogenesis (NST) during mild cold exposure (2015)
  • Author(s): Nishimura T, Motoi M, Egashira Y, Choi D, Aoyagi K, Watanuki S.
  • Journal Title: Journal of Physiological Anthropology Volume: 34 Issue: 1 Pages: 11-11
  • DOI: 10.1186/s40101-015-0051-9
  • NAID: 120006987089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] ボリビア高地集団における循環動態の適応とその性差について (2017)
  • Author(s): 西村 貴孝, 大西 真由美, 西原 三佳Juan Ugarte, 安河内 彦輝, 福田 英輝, 安部 恵代, 有馬 和彦, 富田 義人, 本井 碧, 綿貫 茂喜, 青柳 潔．
  • Organizer: 日本生理人類学会第75 回大会
• [Presentation] UCP1 genotype changes non-shivering thermogenesis under mild cold environment (2016)
  • Author(s): Nishimura T, Katsumura T, Motoi M, Oota H, Watanuki S
  • Organizer: Conference of "Modernization and Health in the Asia-Pacific Region"
  • Place of Presentation: Hilo, Hawaii, USA
  • Year and Date: 2016-08-19
  • Int'l Joint Research
• [Presentation] The relationship between 5-HTTLPR and Event-related Potentials (ERPs) during affective picture processing of different objects. (2016)
  • Author(s): M MOTOI, F Kishida, Y Egashira, N Minote, S Watanuki.
  • Organizer: Conference of "Modernization and Health in the Asia-Pacific Region"
  • Place of Presentation: Hilo, Hawaii, USA
  • Year and Date: 2016-08-19
  • Int'l Joint Research
• [Presentation] 低酸素環境下における事象関連電位とミトコンドリアDNAハプロタイプの関連 (2016)
  • Author(s): 本井碧, 黒田知宏, 岸田文, 西村貴孝, 綿貫茂喜
  • Organizer: 日本生理人類学会第73回大会
  • Place of Presentation: 大阪市立大学（大阪府・大阪市）
  • Year and Date: 2016-06-04
• [Presentation] UCP1 genotype changes thermogenesis and its important role for human cold adaptation (2016)
  • Author(s): Takayuki Nishimura
  • Organizer: JPA/JSPA/UTAR Seminar on Physiological Anthropology 2016
  • Place of Presentation: カンパー（馬国）
  • Year and Date: 2016-03-03
  • Int'l Joint Research / Invited
• [Presentation] 寒冷適応に関わるUCP1 遺伝子型間のヒトにおける熱産生反応の違い (2015)
  • Author(s): 西村貴孝，勝村啓史，本井碧，太田博樹，綿貫茂喜
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 産業技術総合研究所臨海副都心センター（東京都・江東区）
  • Year and Date: 2015-10-01