The development of non-invasive new immune adjuvant using enzymatically synthesized-lignin polymer
| Project/Area Number |
15K18701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リグニン / 抗原リグニン複合体 / DDS / 抗原特異的IgE |
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| Outline of Final Research Achievements |
Lignin is the aromatic biopolymer composed by phenylpropanoids and constitutes the plant cell walls together with hemicellulose and cellulose. It is also known as the dietary fiber that regulates the intestinal environment, and soluble synthetic lignin prepared by peroxidase has been shown to exhibit immunoenhancing activity. To evaluate whether the lignin polymer could be applied as a novel immunoadjuvant material or not, a lignin-antigen complex was synthesized and analyzed the transport of the lignin-antigen complex to macrophages and the antibody-producing activity in the mouse.
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Report
(4 results)
Research Products
(8 results)
