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The development of non-invasive new immune adjuvant using enzymatically synthesized-lignin polymer

Research Project

Project/Area Number 15K18701
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Yamanaka Daisuke  東京薬科大学, 薬学部, 助教 (70734599)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsリグニン / 抗原リグニン複合体 / DDS / 抗原特異的IgE
Outline of Final Research Achievements

Lignin is the aromatic biopolymer composed by phenylpropanoids and constitutes the plant cell walls together with hemicellulose and cellulose. It is also known as the dietary fiber that regulates the intestinal environment, and soluble synthetic lignin prepared by peroxidase has been shown to exhibit immunoenhancing activity. To evaluate whether the lignin polymer could be applied as a novel immunoadjuvant material or not, a lignin-antigen complex was synthesized and analyzed the transport of the lignin-antigen complex to macrophages and the antibody-producing activity in the mouse.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 Other

All Presentation (6 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] マクロファージにおけるリグニンポリマー認識メカニズムの解析2017

    • Author(s)
      山中 大輔, 安達 禎之, 大野 尚仁
    • Organizer
      第13回日本食品免疫学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マクロファージにおけるリグニンポリマー認識メカニズムの解析リグニン様ポリフェノールによるアジュバント効果の解析2017

    • Author(s)
      坂野 由幸, 山中 大輔, 石橋 健一, 安達 禎之, 大野 尚仁
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リグニン様ポリフェノールによる新規アジュバントの開発2017

    • Author(s)
      奥山 直哉,山中 大輔,石橋 健一,安達 禎之,大野 尚仁
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Related Report
      2016 Research-status Report
  • [Presentation] リグニンによるマクロファージ活性化と細胞内シグナル伝達機構の解析2017

    • Author(s)
      荻島 成美,山中 大輔,石橋 健一,安達 禎之,大野 尚仁
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Related Report
      2016 Research-status Report
  • [Presentation] マウスマクロファージによるリグニン標識ビーズ取り込み機構の解析2016

    • Author(s)
      冨岡 太一,山中 大輔,石橋 健一,安達 禎之,大野 尚仁
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 磁気ビーズを用いた新規リグニン認識タンパク質の探索2016

    • Author(s)
      遠藤麻穂,山中 大輔,石橋 健一,安達 禎之,大野 尚仁
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京薬科大学 薬学部 免疫学教室

    • URL

      http://www.ps.toyaku.ac.jp/wp/menekigaku/archives/category/works

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 免疫アジュバント2016

    • Inventor(s)
      山中 大輔/大野 尚仁/多田 塁/元井 益郎/ 元井 章智
    • Industrial Property Rights Holder
      山中 大輔/大野 尚仁/多田 塁/元井 益郎/ 元井 章智
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-134901
    • Filing Date
      2016-07-07
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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