| Project/Area Number |
15K18766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Yoneyama Yosuke 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員 (10748289)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | インスリン様成長因子 / インスリン受容体基質 / アセチル化 |
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| Outline of Final Research Achievements |
Myogenic precursor cells contribute to the development of skeletal muscle as well as regeneration after injury. Insulin-like growth factor is an important hormone that regulates the function of myogenic precursor cells including proliferation and differentiation. In this study, we showed that insulin receptor substrate, a mediator of insulin-like growth factor signaling, is acetylated in response to metabolic activity of myogenic precursor cells. We identified a set of enzymes that acetylate or deacetylate insulin receptor substrate. Our study revealed a potential mechanism in which insulin-like growth factor signaling is modulated during myogenesis to coordinate the fate decision of myogenic precursor cells.
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