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Comparison of insulin signaling pathway between broiler and layer type chicks

Research Project

Project/Area Number 15K18770
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Animal production science
Research InstitutionKobe University

Principal Investigator

Saneyasu Takaoki  神戸大学, 農学研究科, 助教 (20721236)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsインスリン / 視床下部 / 骨格筋 / ブロイラー / レイヤー / Akt / FOXO / S6 / IRS / mTOR
Outline of Final Research Achievements

In this study, we compared regulatory mechanisms of insulin signaling pathway in hypothalamus and skeletal muscle between broiler and layer type chicks. The results in hypothalamus suggest that insulin signaling responds to the change of plasma insulin concentration in both types, and that there may be no difference in regulatory mechanisms of insulin signaling pathway between broiler and layer chicks. The results in skeletal muscle suggest that plasma insulin but not skeletal IGF-1 regulates insulin signaling pathway in response to feeding conditions in both types of chicks and showed that the levels of insulin signaling-related factors are higher in broiler than in layer type chicks.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] The IGF-1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching.2017

    • Author(s)
      1.Saneyasu T, Tsuchihashi T, Kitashiro A, Tsuchii N, Kimura S, Honda K, Kamisoyama H.
    • Journal Title

      Animal Science Journal

      Volume: 印刷中

    • NAID

      120006398782

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The IGF-1/Akt/S6 Signaling Pathway is Age-Dependently Downregulated in the Chicken Breast Muscle2016

    • Author(s)
      Saneyasu T, Inui M, Kimura S, Yoshimoto Y, Tsuchii N, Shindo H, Honda K, Kamisoyama H
    • Journal Title

      The Journal of Poultry Science

      Volume: 53 Issue: 3 Pages: 213-219

    • DOI

      10.2141/jpsa.0150171

    • NAID

      130005166201

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 短時間の絶食がブロイラーの骨格筋におけるタンパク質代謝関連因子の発現量に及ぼす影響2016

    • Author(s)
      槌井七海、来代紋菜、土橋竜也、進藤悠、實安隆興、本田和久、上曽山博
    • Organizer
      日本家禽学会2016年度春季大会
    • Place of Presentation
      日本獣医生命科学大学(東京都・武蔵野市)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] ニワトリにおけるインスリンによる摂食抑制に視床下部mTORは関与していない2016

    • Author(s)
      来代紋菜、槌井七海、土橋竜也、進藤悠、實安隆興、本田和久、上曽山博
    • Organizer
      日本家禽学会2016年度春季大会
    • Place of Presentation
      日本獣医生命科学大学(東京都・武蔵野市)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 新生ヒナの骨格筋におけるタンパク質合成関連因子の発現変動2016

    • Author(s)
      土橋竜也、木村沙也加、来代紋菜、槌井七海、進藤悠、實安隆興、本田和久、上曽山博
    • Organizer
      日本家禽学会2016年度春季大会
    • Place of Presentation
      日本獣医生命科学大学(東京都・武蔵野市)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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