Analysis of genetic diversity and host-specificity of non-primate hepacivirus
Project/Area Number |
15K18779
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Veterinary medical science
|
Research Institution | University of Yamanashi |
Principal Investigator |
TANAKA Tomohisa 山梨大学, 大学院総合研究部, 特任助教 (30585310)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | へパシウイルス / 翻訳 / ゲノム複製 / 多様性 / 非翻訳領域 / ヘパシウイルス / 疫学 / ウイルス / 翻訳開始 / C型肝炎ウイルス |
Outline of Final Research Achievements |
Non-primate hepacivirus (NPHV) is thought to share the ancestor with hepatitis C virus (HCV), which is an important viral model for elucidating the origin, pathogenicity or host-tropism of HCV. However, the epidemiological or virological evidence is still poor. In this study, we isolated NPHV from some endemic species in Japan and phylogenetically analyzed them in order to elucidate the genetic diversity of NPHV. Moreover, we investigated the mechanisms of equine hepacivirus (EHcV) 5’ UTR in IRES-dependent translation initiation and the association of EHcV 5’ UTR with miR-122-indepdendent viral replication.
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Report
(4 results)
Research Products
(8 results)