Development of novel asymmetric catalyst based on piperazinone derivatives
| Project/Area Number |
15K18829
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
NAKAO Michiyasu 徳島大学, 大学院医歯薬学研究部(薬学系), 助教 (60550001)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ピペラジノン / 不斉触媒 / 不斉アルドール反応 / 環状炭酸エステル / 非対称化反応 |
|---|
| Outline of Final Research Achievements |
We investigated that development of novel asymmetric catalyst based on piperazinone derivatives. As a result, we demonstrated that novel piperazinone bearing a primary amino group could catalyze asymmetric aldol reaction between hydroxyacetone and p-nitrobenzaldehyde. In addition, novel piperazinone bearing a tertiary amino group was found to catalyze asymmetric desymmetrization of σ-symmetric cyclic carbonates.
|
Report
(3 results)
Research Products
(1 results)
