| Project/Area Number |
15K18831
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Shigeki 九州大学, 大学院薬学研究院, 教授 (10170672)
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| Research Collaborator |
OBAYASHI Hideto
FUKUDA Takashi
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 捕捉分子 / 分子認識 / 酸化損傷塩基 / 8-ニトログアノシン / 8-チオグアノシン / 8-オキソグアノシン / 水素結合 |
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| Outline of Final Research Achievements |
In this study, we have been developing the novel molecular probes for the 8-nitro-cGMP or the 8-thio-cGMP as signal molecules formed by the reactive nitrogen species in cells. These probes with covalent reactivity in a cell condition may be available for a detecting tool or a drug candidate. We synthesized the new nitroG-Grasp and 8-thioG-grasp to increase the reactivity. Indeed, the new nitroG-Grasp molecule exhibited high reactivity in the neutral aqueous condition. We found an interesting character of 8-thioguanosine when the capture reaction was performed using the novel 8-thioG-grasp. The model compounds with the cyclen-zinc complex were synthesized due to recognize the phosphates in the water. These fluorescence metal complexes exhibited as a molecular probe for 8-oxo-dGTP.
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