Development of magnetically guided M2 macrophages-based cell therapy for inflammatory bowel disease
| Project/Area Number |
15K18851
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Kono Yusuke 立命館大学, 薬学部, 助教 (60732823)
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| Research Collaborator |
FUJITA TAKUYA 立命館大学, 薬学部, 教授 (00247785)
KONISHI SATOSHI 立命館大学, 理工学部, 教授 (50288627)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 磁場応答性リポソーム / 細胞送達システム / M2型マクロファージ / マクロファージ / 磁場 / リポソーム / 炎症性腸疾患 |
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| Outline of Final Research Achievements |
In order to develop the macrophages-based cell therapy for inflammatory bowel disease, it is necessary to construct the colon-selective cell delivery system. In this study, we have succeeded in efficiently delivering magnetic liposomes/plasmid DNA complexes-introduced macrophages to the region where an external magnetic field is exposed. In addition, we have demonstrated that these macrophages exhibit anti-inflammatory M2 phenotype, and have an ability to convert the phenotype of surrounding macrophages to M2.
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Report
(3 results)
Research Products
(21 results)
