The analysis of neudesin, a secretory molecule, for developing an anti-obesity drug

• Project/Area Number: 15K18863
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Nagoya University (2016); Kobe Pharmaceutical University (2015)
• Principal Investigator: Ohta Hiroya 名古屋大学, 環境医学研究所, 助教 (40638988)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: neudesin / ノルアドレナリン / 交感神経系 / 脂肪組織

Outline of Final Research Achievements

We previously reported that the neudesin KO mice were resistant to diet-induced obesity. neudesin KO mice showed increased energy expenditure due to increased sympathetic nervous activity. We newly found that recombinant neudesin protein acted on differentiated PC12 cells to suppress tyrosine hydroxylase (Th), which is a rate-limiting enzyme of noradrenaline synthesis. We also found that neudesin directly acted on white adipocytes to suppress adrenaergic stimuli on adipocytes.

Research Products

• [Journal Article] Fgf21 regulates T-cell development in the neonatal and juvenile thymus. (2017)
  • Author(s): Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M
  • Journal Title: Scientific Reports Volume: 23 Issue: 1 Pages: 330-330
  • DOI: 10.1038/s41598-017-00349-8
  • NAID: 120006305890
  • Peer Reviewed / Open Access
• [Journal Article] Roles of FGF Signals in Heart Development, Health, and Disease. (2016)
  • Author(s): Itoh N, Ohta H, Nakayama Y, Konishi M.
  • Journal Title: Front Cell Dev Biol Volume: 4 Pages: 110-110
  • DOI: 10.3389/fcell.2016.00110
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of the secretory protein neudesin in energy metabolism (2016)
  • Author(s): Ohta H
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 5 Issue: 3 Pages: 229-233
  • DOI: 10.7600/jpfsm.5.229
  • NAID: 130005165308
  • ISSN: 2186-8123, 2186-8131
  • Peer Reviewed / Open Access
• [Journal Article] Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy. (2015)
  • Author(s): Itoh N, Ohta H, Konishi M.
  • Journal Title: Frontier Endocrinology (Lausanne). Volume: 6 Pages: 1-9
  • DOI: 10.3389/fendo.2015.00154
  • Peer Reviewed / Open Access
• [Journal Article] Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis (2015)
  • Author(s): Ohta H, Kimura I, Konishi M, Itoh N
  • Journal Title: frontiers in Molecular Biosciences Volume: 2 Pages: 24-24
  • DOI: 10.3389/fmolb.2015.00024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deletion of Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity (2015)
  • Author(s): Hiroya Ohta, Morichika Konishi, Yusuke Kobayashi, Atsuki Kashio, Takayuki Mochiyama, Shigenobu Matsumura, Kazuo Inoue, Tohru Fushiki, Kazuwa Nakao, Ikuo Kimura, Nobuyuki Itoh
  • Journal Title: Scientific Reports Volume: 印刷中 Issue: 1 Pages: 10049-10049
  • DOI: 10.1038/srep10049
  • NAID: 120005753823
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 新規分泌性因子neudesinによるエネルギー代謝調節機構の解明 (2016)
  • Author(s): 太田紘也, 小西守周, 中尾一和, 木村郁夫, 伊藤信行
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-07
• [Presentation] 液性因子neudesinによるエネルギー代謝調節機構の解明 (2016)
  • Author(s): 太田紘也, 小西守周, 木村郁夫, 菅波孝祥, 伊藤信行
  • Organizer: 第６回 生理学研究所・名古屋大学医学系研究科 合同シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2016-09-24
• [Presentation] 分泌性因子neudesinの遺伝子欠損マウスでは白色脂肪の褐色化が亢進した (2016)
  • Author(s): 太田紘也, 齋藤優太, 中山喜明, 増田有紀, 木村郁夫, 伊藤信行, 小西守周
  • Organizer: 第63回生化学会近畿支部例会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-21
• [Presentation] 分泌性因子neudesinの遺伝子欠損マウスは交感神経活性の亢進により食餌誘導性肥満に耐性示す (2015)
  • Author(s): 太田紘也, 小西守周, 橋本大嗣, 樫尾篤樹, 持山喬之, 松村成暢, 井上和生, 伏木亨, 中山喜明, 中尾一和, 木村郁夫, 伊藤信行
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-03
• [Presentation] 肥満に関わる分泌性因子neudesinの同定と解析 (2015)
  • Author(s): 太田紘也, 小西守周, 松村成暢, 井上和生, 伏木亨, 中尾一和, 木村郁夫, 伊藤信行
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-19
  • Invited
• [Presentation] 神経栄養因子neudesinの遺伝子欠損マウスは高脂肪食誘導性肥満に耐性を示した (2015)
  • Author(s): 太田紘也, 小西守周, 松村成暢, 井上和生, 伏木亨, 中尾一和, 木村郁夫, 伊藤信行
  • Organizer: 第20回アディポサイエンス・シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2015-08-22