Physiological regulation of lipid homeostasis by prostaglandin EP4 receptor
Project/Area Number |
15K18875
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
|
Research Institution | Kumamoto University |
Principal Investigator |
Inazumi Tomoaki 熊本大学, 大学院生命科学研究部(薬), 助教 (80746503)
|
Research Collaborator |
YAMADA Kiyotaka
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | プロスタグランジン受容体 / 脂質代謝 |
Outline of Final Research Achievements |
In this study, we found that prostaglandin (PG) E2-EP4 receptor pathway regulates physiological lipid distribution by changing the lipid accumulation balance between adipose tissue and liver. Adipocyte-specific EP4 KO mice showed increased adiposity like in global KO mice, suggesting that PGE2 mainly acts on EP4 receptor in adipocyte. Moreover, EP4 agonist treatment to diet-induced obesity mice changed the lipid distribution in several tissues. These results show the possibility that EP4 receptor may be useful as a therapeutic target of dyslipidemia.
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Report
(4 results)
Research Products
(13 results)