| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Methylmercury (MeHg) did not exacerbate the pathology of food allergy and atopy model mice in which the immune response is enhanced.
Herbal derived compounds were explored about inhibitory effects of methylmercury (MeHg) toxicity. SA006 treatment significantly increased cell viability and suppressed cellular intake of MeHg in MeHg exposure cells. To verify the therapeutic effects of these compounds on the MeHg toxicity, mice were administered MeHg with/without pretreatment of SA006 5 times a week for 4 weeks. SA006 significantly decreased MeHg accumulation in liver, kidney, spleen, cerebrum and cerebellum. These results suggested SA006 inhibits MeHg toxicity by suppressing an accumulation of MeHg in organs.
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