| Project/Area Number |
15K18898
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
FUKUDA Hayato 北海道大学, 薬学研究院, 助教 (30434450)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レゾルビン / レゾルビンE2 / 安定等価体 / 標的タンパク質 / 炎症収束 / シクロプロパン / デオキシレゾルビン / 不飽和脂肪酸 / 抗炎症活性 / 標的タンパク / 構造活性相関 / レゾルビン類 |
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| Outline of Final Research Achievements |
It was decided to synthesize deoxyresolvine E2 in order to confirm the importance of the hydroxyl group of resolvin E2, then 5-deoxyresolvin E2, 18-deoxyresolvin E2, and 5,18-dideoxyresolvin E2 were efficiently synthesized by exploiting the synthetic method of resolvin E2. These synthesized compounds were evaluated by an anti-inflammatory activity test, so it was found that they all had the biological activity equivalent to that of resolvin E2. Therefore, it was suggested that the linker could extend from C-5 or C-18 of resolvin E2.
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