Molecular mechanism underling improvement of oxaliplatin-induced neuropathy by duloxetine
| Project/Area Number |
15K18922
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University (2016-2017)
Kyushu University (2015) |
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Principal Investigator |
Kajiwara Moto 京都大学, 医学研究科, 薬剤師(特定) (70645506)
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| Research Collaborator |
MASUDA Satohiro 九州大学, 病院薬剤部, 教授・薬剤部長
MATSUBARA Kazuo 京都大学, 医学部附属病院薬剤部, 教授・薬剤部長
NAKAGAWA Shunsaku 京都大学, 医学部附属病院薬剤部, 助教
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | トランスポーター / オキサリプラチン / 末梢神経障害 / 有機カチオントランスポーター / 後根神経節細胞 |
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| Outline of Final Research Achievements |
HEK293 cells transiently expressing human (h) or rat (r) oraganic cation transporter (OCT) were treated with oxaliplatin (L-OHP) and various concentrations of duloxetine (DLX). Lactate dehydrogenase activity and caspase activity induced by L-OHP was reduced by DLX treatment. Amount of Pt accumulated in cells was also decreased by DLX treatment. Those results suggested that DLX improved L-OHP induced peripheral neuropathy by interfering with L-OHP incorporation in dorsal root ganglion.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Protective Effects of Imatinib on Ischemia/Reperfusion Injury in Rat Lung.2016
Author(s)
Tanaka S, Chen-Yoshikawa TF, Kajiwara M, Menju T, Ohata K, Takahashi M, Kondo T, Hijiya K, Motoyama H, Aoyama A, Masuda S & Date H
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Journal Title
Ann Thorac Surg.
Volume: 102
Pages: 1717-1724
DOI
Related Report
Peer Reviewed
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[Journal Article] Molecular markers of tubulointerstitial fibrosis and tubular cell damage in patients with chronic kidney disease2015
Author(s)
Nakagawa S, Nishihara K, Miyata H, Shinke H, Tomita E, Kajiwara M, Matsubara T, Iehara N, Igarashi Y, Yamada H, Fukatsu A, Yanagita M, Matsubara K & Masuda S
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Journal Title
PLoS ONE
Volume: 10
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Analysis of the variable factors in the blood tacrolimus concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation2015
Author(s)
Kimitaka Suetsugu, Hiroaki Ikesue, Mayako Uchida, Takahisa Yano, Hiroyuki Watanabe, Takaaki Yamada, Takehiro Kawashiri, Moto Kajiwara, Toshihiro Miyamoto, Motoaki Shiratsuchi, Nobuaki Egashira, Satohiro Masuda
Organizer
The 14th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
Place of Presentation
Rotterdam (Netherlands)
Year and Date
2015-10-11
Related Report
Int'l Joint Research
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