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Molecular mechanism underling improvement of oxaliplatin-induced neuropathy by duloxetine

Research Project

Project/Area Number 15K18922
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionKyoto University (2016-2017)
Kyushu University (2015)

Principal Investigator

Kajiwara Moto  京都大学, 医学研究科, 薬剤師(特定) (70645506)

Research Collaborator MASUDA Satohiro  九州大学, 病院薬剤部, 教授・薬剤部長
MATSUBARA Kazuo  京都大学, 医学部附属病院薬剤部, 教授・薬剤部長
NAKAGAWA Shunsaku  京都大学, 医学部附属病院薬剤部, 助教
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsトランスポーター / オキサリプラチン / 末梢神経障害 / 有機カチオントランスポーター / 後根神経節細胞
Outline of Final Research Achievements

HEK293 cells transiently expressing human (h) or rat (r) oraganic cation transporter (OCT) were treated with oxaliplatin (L-OHP) and various concentrations of duloxetine (DLX). Lactate dehydrogenase activity and caspase activity induced by L-OHP was reduced by DLX treatment. Amount of Pt accumulated in cells was also decreased by DLX treatment. Those results suggested that DLX improved L-OHP induced peripheral neuropathy by interfering with L-OHP incorporation in dorsal root ganglion.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2018 2017 2016 2015

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Journal Article] Role of mTOR Inhibitors in Kidney Disease.2016

    • Author(s)
      Kajiwara M & Masuda S
    • Journal Title

      Int J Mol Sci

      Volume: 17 Issue: 6 Pages: 975-975

    • DOI

      10.3390/ijms17060975

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Urinary Dopamine as a Potential Index of the Transport Activity of Multidrug and Toxin Extrusion in the Kidney2016

    • Author(s)
      Kajiwara M, Ban T, Matsubara K, Nakanishi Y & Masuda S
    • Journal Title

      Int J Mol Sci

      Volume: 17 Issue: 8 Pages: 1228-1228

    • DOI

      10.3390/ijms17081228

    • NAID

      120005838149

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protective Effects of Imatinib on Ischemia/Reperfusion Injury in Rat Lung2016

    • Author(s)
      Tanaka S, Chen-Yoshikawa TF, Kajiwara M, Menju T, Ohata K, Takahashi M, Kondo T, Hijiya K, Motoyama H, Aoyama A, Masuda S & Date H
    • Journal Title

      Ann Thorac Surg

      Volume: 102 Issue: 5 Pages: 1717-1724

    • DOI

      10.1016/j.athoracsur.2016.05.037

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] メトトレキサート血中濃度測定における化学発光免疫測定法(CLIA法)と従来法との比較検討2016

    • Author(s)
      矢野貴久、川尻雄大、山田孝明、末次王卓、山本奈々絵、土谷祐一、松川公美、梶原望渡、増田智先
    • Journal Title

      TDM研究

      Volume: 33 Pages: 9-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 電気化学免疫測定法(ECLIA法)を用いたtacrolimusおよびcyclosporin A血中濃度測定に関する臨床的評価2016

    • Author(s)
      矢野貴久、川尻雄大、末次王卓、山田孝明、山本奈々絵、梶原望渡、増田智先
    • Journal Title

      移植

      Volume: 51 Pages: 58-58

    • NAID

      130005139942

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抗がん薬とトランスポーター2016

    • Author(s)
      梶原望渡、増田智先
    • Journal Title

      月刊薬事

      Volume: 58 Pages: 221-221

    • Related Report
      2015 Research-status Report
  • [Journal Article] Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease2015

    • Author(s)
      Nakagawa S, Nishihara K, Miyata H, Shinke H, Tomita E, Kajiwara M, Matsubara T, Iehara N, Igarashi Y, Yamada H, Fukatsu A, Yanagita M, Matsubara K & Masuda S
    • Journal Title

      PLoS One

      Volume: 10 Issue: 8 Pages: 1-14

    • DOI

      10.1371/journal.pone.0136994

    • NAID

      120005763422

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] トランスポーターがかかわる薬物間相互作用2015

    • Author(s)
      梶原望渡、増田智先
    • Journal Title

      日病薬誌

      Volume: 51 Pages: 967-967

    • Related Report
      2015 Research-status Report
  • [Journal Article] 腎臓のトランスポーターと化学療法剤2015

    • Author(s)
      梶原望渡、増田智先
    • Journal Title

      化学療法の領域

      Volume: 31 Pages: 62-62

    • Related Report
      2015 Research-status Report
  • [Presentation] デュロキセチンのオキサリプラチン誘発性末梢神経障害抑制メカニズムの解明2018

    • Author(s)
      梶原 望渡, 中川 俊作, 松原 和夫, 増田 智先
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 測定法の多様性2017

    • Author(s)
      梶原望渡
    • Organizer
      第34回日本TDM学会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腎局所で産生されるドパミンの尿細管分泌を担うMATEトランスポーターの機能障害は体液貯留を引き起こす2017

    • Author(s)
      梶原 望渡, 伴 毅, 中西 洋一, 松原 和夫, 増田 智先
    • Organizer
      第27回日本医療薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん化学療法における腎異物排泄機構の重要性2015

    • Author(s)
      増田 智先、梶原 望渡
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀 (東京)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Impact of Tubular Luminal H+/organic cation antiporter, MATE, on Imatinib-induced Fluid Retention2015

    • Author(s)
      M. Kajiwara, S. Masuda
    • Organizer
      kidney week 2015 (ASN2015)
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of the variable factors in the blood tacrolimus concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation2015

    • Author(s)
      Kimitaka Suetsugu, Hiroaki Ikesue, Mayako Uchida, Takahisa Yano, Hiroyuki Watanabe, Takaaki Yamada, Takehiro Kawashiri, Moto Kajiwara, Toshihiro Miyamoto, Motoaki Shiratsuchi, Nobuaki Egashira, Satohiro Masuda
    • Organizer
      The 14th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
    • Place of Presentation
      Rotterdam (Netherlands)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ECLIA法を用いたタクロリムスおよびシクロスポリンの血中濃度測定に関する臨床的評価2015

    • Author(s)
      川尻 雄大、矢野 貴久、末次 王卓、山田 孝明、梶原 望渡、増田 智先
    • Organizer
      第51回日本移植学会
    • Place of Presentation
      ホテル日航熊本、熊本公徳会武道場 (熊本県)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Gene expression analysis of isolated proximal tubules in rat model of tacrolimus-induced chronic kidney disease2015

    • Author(s)
      M. Kajiwara, Y. Tamura, H. Shinke, S. Nakagawa, T. Yano, K. Matsubara, S. Masuda
    • Organizer
      2nd International Caparica Conference on Urine Omics & 2nd International Caparica Conference In Translational Nephrology
    • Place of Presentation
      Caparica (Portugal)
    • Year and Date
      2015-09-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of a useful biomarker for tacrolimus-induced nephrotoxicity in liver transplant patients2015

    • Author(s)
      S. Masuda, M. Kajiwara, N Tsuchimoto, H. Shinke, M. Uesugi, S. Uemoto, K. Matsubara
    • Organizer
      2nd International Caparica Conference on Urine Omics & 2nd International Caparica Conference In Translational Nephrology
    • Place of Presentation
      Caparica (Portugal)
    • Year and Date
      2015-09-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Critical role of renal H+/organic cation antiporter (multidrug and toxin extrusion) in natriuresis as a dopamine transporter2015

    • Author(s)
      Moto Kajiwara, Satohiro Masuda
    • Organizer
      BioMedical Transporters 2015
    • Place of Presentation
      Lugano (Switzerland)
    • Year and Date
      2015-08-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] MATEを介するドパミンの尿細管分泌はNa+利尿を促進する2015

    • Author(s)
      梶原 望渡, 伴 毅, 花田 有希, 松原 和夫, 増田 智先
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] メトトレキサート血中濃度測定における化学発光免疫測定法(CLIA法)と従来法との比較検討2015

    • Author(s)
      矢野 貴久、川尻 雄大、山田 孝明、末次 王卓、梶原 望渡、増田 智先
    • Organizer
      第32回日本TDM学会・学術大会
    • Place of Presentation
      キッセイ文化ホール (長野県)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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