The development of intranasal vaccine using liposomes against fungal infections
Project/Area Number |
15K18935
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
Tada Rui 東京薬科大学, 薬学部, 講師 (70635888)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 粘膜ワクチン / 真菌感染症 / リポソーム / 粘膜アジュバント / 真菌症 / DDS / Candida albicans / Aspergillus fumigatus |
Outline of Final Research Achievements |
Mucosal vaccine systems are a promising therapeutic strategy for preventing and/or treating fungal infection, which is increasingly becoming associated with immunosuppressive conditions. We have recently found that intranasal administration of an antigenic protein with the DOTAP/DC-chol liposomes induced antigen-specific mucosal and systemic antibody responses in mice. Here, we attempted to develop a cationic liposome-based nasal vaccine against invasive fungal infections. As results, intranasal administration of DOTAP/DC-chol liposomes with CaSap2p and AfAspf3p, which are derived from Candida albicans and Aspergillus fumigatus, respectively, induced antigen-specific mucosal IgA, systemic IgG, Th17 immune responses in mice.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] The Dual Activity Responsible for the Elongation and Branching of β-(1,3)-Glucan in the Fungal Cell Wall.2017
Author(s)
Aimanianda V, Simenel C, Garnaud C, Clavaud C, Tada R, Barbin L, Mouyna I, Heddergott C, Popolo L, Ohya Y, Delepierre M, Latge JP
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice2015
Author(s)
Rui Tada, Akira Hidaka, Naoko Iwase, Saeko Takahashi, Yuki Yamakita, Tomoko Iwata, Shoko Muto, Emi Sato, Noriko Takayama, Emi Honjo, Hiroshi Kiyono, Jun Kunisawa,Yukihiko Aramaki
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Journal Title
PLoS ONE
Volume: 10(10)
Issue: 10
Pages: e0139785-e0139785
DOI
Related Report
Peer Reviewed / Open Access
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