Population pharmacokinetic-pharmacodynamic model analysis of drug plasma concentration in cancer chemotherapy
| Project/Area Number |
15K18937
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 母集団薬物動態解析 / 薬物動態-薬力学的（PK-PD）モデル解析 / 個別化医療 / フッ化ピリミジン系抗がん剤 / 薬物動態－薬力学的（PK-PD）モデル解析 / 日内変動 / がん化学療法 / 経口フッ化ピリミジン系抗がん剤 / 母集団解析 / 薬物動態－薬力学的（PK-PD）解析 / 骨髄抑制 / 抗がん剤 / 5-フルオロウラシル |
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| Outline of Final Research Achievements |
To develop the personalized chemotherapeutic strategies based on a pharmacokinetic-guided administration of 5-fluorouracil (5-FU), population pharmacokinetic model analysis were performed and pharmacokinetic-pharmacodynamic (PK-PD) models were constructed. Inter- and intra-individual variations in plasma concentrations of 5-FU and myelosuppression were evaluated using rats. Circadian patterns of clearance of 5-FU could be characterized and the population PK-PD model successfully described the time-course alterations and individual predictions of the blood cell counts after administration of 5-FU. These findings provide useful information on the cost-effective chemotherapeutic strategies and contribute to improve clinical outcome.
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Report
(4 results)
Research Products
(37 results)
