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Study on the drug exercise therapy that is effective for cardiac hypertrophy heart failure that develops in Ca2 + load model mouse

Research Project

Project/Area Number 15K18975
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

JIN MEIHUA  国立研究開発法人国立循環器病研究センター, 研究所, 研究員 (40746773)

Co-Investigator(Renkei-kenkyūsha) Wakabayashi Shigeo  大阪医科大学, 医学研究科・薬理学教室, 研究員 (70158583)
Research Collaborator Shirai Mikiyasu  国立循環器病研究センター, 肺高血圧症先端医学研究部, 特任研究員 (70162758)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsheart failure / hypertrophy / hypoxia / Ca2+-binding protein / 肺高血圧 / 心肥大 / Ca2+結合蛋白質 / 低酸素負荷 / CHP3欠損マウス / 心不全 / NHE1 / Ca2+シグナル / ベータ遮断薬 / CHP3
Outline of Final Research Achievements

Since Na+ / H+ exchanger (NHE1)-overexpressed mice are difficult to reproduce, we modified the original schedule. Using knockout mice, we analyzed the function of calcineurin B-like protein (CHP) 3 which were closely related to NHE1 in vivo. The results indicated that the cardiac function and the cardiac weight of CHP3-deficient mice at the baseline were not different from those of the wild type mice. A chronic hypoxia induced the right ventricle hypertrophy in the wild-type mice. In contrast, interestingly, in addition to the right ventricle it caused a significant left ventricle hypertrophy in the CHP3-deficient mice. In addition, since the expression of CHP3 in the heart of the wild type mice was markedly decreased by hypoxia. Thus, it was suggested that CHP3 could be an important molecule that might negatively regulate cardiac hypertrophy caused by hypoxic stimulation, by controlling the expression level.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.2016

    • Author(s)
      Jin H,Fujita T,Jin M,Kurotani R,Hidaka Y,Cai W,Suita K,Prajapati R,Liang C,Ohnuki Y,Mototani Y,Umemura M,Yokoyama U,Sato M,Okumura S,Ishikawa Y.
    • Journal Title

      J Physiol Sci.

      Volume: 印刷中 Issue: 1 Pages: 77-87

    • DOI

      10.1007/s12576-016-0509-5

    • NAID

      40021443658

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of inflammatory factor-induced cyclo-oxygenase expression on the development of reperfusion-related no-reflow phenomenon in acute myocardial infarction2015

    • Author(s)
      Qibin Jiao, Qiang Ke, Weiwei Li, MeiHua Jin, YanLuo, Linan Zhang, DongYang and Xingwei Zhang
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 42 Issue: 2 Pages: 162-170

    • DOI

      10.1111/1440-1681.12339

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function.2015

    • Author(s)
      Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 310(1) Issue: 1 Pages: 92-103

    • DOI

      10.1152/ajpheart.00411.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A Novel Role of Calcineurin B Homologous Protein 3 in Hypoxia-induced Cardiac Hypertrophy and Heart Failure2017

    • Author(s)
      MeiHua Jin, Shigeo Wakabayashi, Soushi Kobayashi, Hirotsugu Tsuchimochi, Mikiyasu Shirai, James T. Pearson, Takeshi Ogo.
    • Organizer
      The 94th Annual Meeting of the Phisiological Society
    • Place of Presentation
      Hamamatu
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Production of calcineurin B homologous protein 3 knockout mice and analysis of cardiac function2016

    • Author(s)
      Shigeo Wakabayashi,MeiHua Jin, Soushi Kobayashi, Hirotsugu Tsuchimochi, Mikiyasu Shirai
    • Organizer
      The 93th Annual Meeting of the Phisiological Society
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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