| Project/Area Number |
15K18991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Research Collaborator |
Takeya Ryu 宮崎大学, 医学部, 教授 (50335981)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Insulin2 / アクチン細胞骨格 / Fhod3 / Proinsulin / actin cytoskeleton / インスリン / C57BL/6マウス |
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| Outline of Final Research Achievements |
Recent reports show that brain-derived insulin exists in the brain. However, little is known of the production mechanism and physiological roles. In this study, we analyzed expression of insulin2 in mouse brain. As the result, insulin2 mRNA and precursor were expressed in mouse brain, suggesting the possibly that insulin2 is synthesized in mouse brain. We also analyzed the regulatory mechanism of actin cytoskeleton, which is expected to be involved insulin secretion in neurons. We obtained results suggesting that the formin protein Fhod3, one of the actin polymerization factors, controls the actin cytoskeleton of nerve cells.
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