| Project/Area Number |
15K19002
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
Hara Taichi 群馬大学, 生体調節研究所, 准教授 (00392374)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | タンパク質品質管理機構 / 初期胚発生 / ゴルジ体 / 細胞膜タンパク質 / 小胞体 / 疾患関連変異膜タンパク質 / 遺伝子欠損マウス / Rer1 / 細胞内膜輸送 / マウス初期胚発生 / 神経発生 / 脳 / 小胞体品質管理 / 多能性幹細胞 |
|---|
| Outline of Final Research Achievements |
Rer1 has been suggested to be involved in the quality control of plasma membrane proteins in the Golgi apparatus. However, its physiological roles and molecular mechanisms in mammal remained to be elucidated. In this study, we generated Rer1 deficient mice and analyzed the phenotype. We confirmed that Rer1 deficient mice were embryonic lethal, indicating that Rer1 has an essential role in mouse early development. We also found that Rer1 regulates the ER retention of some kind of disease-associated membrane proteins.
|
