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Elucidation of regulation of osteogenesis and chondrogenesis by Hippo pathway

Research Project

Project/Area Number 15K19026
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionKyushu University

Principal Investigator

Goto Hiroki  九州大学, 生体防御医学研究所, 助教 (20734495)

Research Collaborator NISHIO Miki  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsHippo経路 / シグナル伝達 / Hippo経路
Outline of Final Research Achievements

Osteoblast-specific Mob1a/1b double homozygous mutant mice showed osteosclerosis with the growth of osteoblasts. Chondrocyte-specific Mob1a/1b double homozygous mutant mice showed short-limb skeletal dysplasia with the reduction of growth plate length. Genes related with extracellular matrix in chondrocyte-specific Mob1 deleted cells were downregulated in vitro. These results indicate that Hippo pathway plays a critical role in the regulation of osteogenesis and chondrogenesis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene2017

    • Author(s)
      Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW, Nakao K, Nakanishi Y, Suzuki A
    • Journal Title

      Oncogene

      Volume: 印刷中 Issue: 29 Pages: 4201-4211

    • DOI

      10.1038/onc.2017.58

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway2017

    • Author(s)
      M. Nishio, T. Maehama, H. Goto, K. Nakatani, W. Kato, H. Omori, Y. Miyachi, H. Togashi, Y. Shimono and A. Suzuki
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 1 Pages: 6-31

    • DOI

      10.1111/gtc.12461

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting the Hippo signalling pathway for cancer treatment2016

    • Author(s)
      K. Nakatani, T. Maehama, M. Nishio, H. Goto, W. Kato, H. Omori, Y. Miyachi, H. Togashi, Y. Shimono and A. Suzuki
    • Journal Title

      J. Biochem.

      Volume: 161 Pages: 237-244

    • DOI

      10.1093/jb/mvw074

    • NAID

      40021162008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysregulated YAP1/TAZ and TGF signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice2015

    • Author(s)
      Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A.
    • Journal Title

      PNAS

      Volume: 113 Issue: 1 Pages: 71-80

    • DOI

      10.1073/pnas.1517188113

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Regulation of chondrogenesis and osteogenesis by Hippo pathway2015

    • Author(s)
      Hiroki Goto, Miki Nishio, Akira Suzuki
    • Organizer
      The 25th Hot Spring Harbor International Symposium, Cutting Edge of Technical Innovations in Structural and Systems Biology 2015
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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