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Characterization of the glycosylation pattern in cholangiolocellular carcinoma

Research Project

Project/Area Number 15K19049
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionUniversity of Fukui

Principal Investigator

Hoshino Hitomi  福井大学, 学術研究院医学系部門, 特命助教 (90500710)

Research Collaborator KOBAYASHI Motohiro  福井大学, 学術研究院医学系部門, 教授 (00362137)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords細胆管細胞癌 / 糖鎖 / MUC1 / EMA
Outline of Final Research Achievements

This study was undertaken to determine whether sulfated glycans could serve as a cholangiolocellular carcinoma (CoCC) marker. We showed that sulfated glycans are preferentially expressed at the apical membrane of cholangiocytes found in small-sized intrahepatic bile ducts in normal liver and in canalicular structures formed in CoCC. We also reported that apical membrane expression of sulfated glycans colocalized with that of mucin 1 (MUC1) core proteins in CoCC. We showed that N-acetylglucosamine-6-O-sulfotransferase 2 (GlcNAc6ST-2) catalyze biosynthesis of sulfated glycans in cholangiocytes. These results indicate that apical membrane localization of MUC1 proteins decorated with GlcNAc6ST-2-dependent sulfated glycans may mark cholangiocytes with cholangiolar/ductular differentiation and could serve as a useful CoCC marker.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Appearance of high endothelial venule-like vessels in benign prostatic hyperplasia is associated with lower urinary tract symptom2017

    • Author(s)
      Inamura S, Shinagawa T, Hoshino H, Sakai Y, Imamura Y, Yokoyama O, Kobayashi M
    • Journal Title

      Prostate

      Volume: 77 Issue: 7 Pages: 794-802

    • DOI

      10.1002/pros.23319

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma2016

    • Author(s)
      Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M
    • Journal Title

      Lab Invest

      Volume: 96 Issue: 12 Pages: 1246-1255

    • DOI

      10.1038/labinvest.2016.104

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High endothelial venule-like vessels and lymphocyte recruitment in diffuse sclerosing variant of papillary thyroid carcinoma.2016

    • Author(s)
      Shulin L, Sakai Y., Hoshino H, Hirokawa M, Kawashima H, Higuchi K, Imamura Y, Kobayashi M
    • Journal Title

      Pathology

      Volume: 48 Issue: 7 Pages: 666-674

    • DOI

      10.1016/j.pathol.2016.08.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A potential role for 6-sulfo sialyl Lewis X in metastasis of bladder urothelial carcinoma2015

    • Author(s)
      Taga M, Hoshino H, Low S, Imamura Y, Ito H, Yokoyama O, Kobayashi M
    • Journal Title

      Urol Oncol

      Volume: 33 Issue: 11 Pages: 496.e1-496.e9

    • DOI

      10.1016/j.urolonc.2015.05.026

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma2017

    • Author(s)
      Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M
    • Organizer
      20th Annual San Diego Glycobiology Symposium
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High endothelial venule-like vessels and lymphocyte recruitment in diffuse sclerosing variant of papillary thyroid carcinoma2017

    • Author(s)
      Low S, Kanamori R, Sakai Y, Hoshino H, Hirokawa M, Kawashima H, Higuchi K, Imamura Y, Kobayashi M
    • Organizer
      20th Annual San Diego Glycobiology Symposium
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma2016

    • Author(s)
      Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M
    • Organizer
      26th Annual conference of the society for Glycobiology
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A potential role for 6-sulfo sialyl Lewis X in metastasis of bladder urothelial carcinoma2016

    • Author(s)
      Taga M, Hoshino H, Los S, Imamura Y, Ito H, Kobayashi M, Yokoyama O
    • Organizer
      American Urology Association Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-05-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膀胱癌に発現する硫酸化シアリルルイスXに関する検討2016

    • Author(s)
      多賀 峰克, 伊藤 英明, 品川 友親, 堤内 真美, 星野 瞳, 小林 基弘, 横山 修
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] A potential role for 6-sulfo sialyl Lewis X in metastasis of bladder urothelial carcinoma2015

    • Author(s)
      Minekatsu Taga, Hitomi Hoshino, Shulin Low, and Motohiro Kobayashi
    • Organizer
      Annual conference of the society for Glycobiology
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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