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Roles of MafK-Gpnmb axis in malignant progression of cancer and molecular targeted therapy

Research Project

Project/Area Number 15K19070
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionUniversity of Tsukuba

Principal Investigator

OKITA Yukari  筑波大学, 医学医療系, 研究員 (30743710)

Research Collaborator KATO Mitsuyasu  筑波大学, 医学医療系, 教授 (20194855)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsMafK / GPNMB / 腫瘍形成 / EMT / 転移形成 / 分子標的治療 / Gpnmb / 環状ペプチド
Outline of Final Research Achievements

Previously we showed that the transcription factor MafK is involved in induction of epithelial-mesenchymal transition (EMT) and malignant progression of breast cancer cells. Furthermore, we identified glycoprotein nmb (GPNMB) as a target of MafK, which also has the functions as an inducer of EMT and tumorigenesis.
In this project, we further investigated the molecular mechanisms how MafK-GPNMB axis contributes to EMT induction and tumorigenesis. Then, we found post-translational modification of MafK is important for functional regulation of MafK in EMT induction and tumorigenesis. Moreover, we identified some domains or motifs which are essential for GPNMB-mediated EMT induction and tumorigenesis. We are going to investigate further detail mechanisms in order to find new target for breast cancer treatment.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] ライデン大学(オランダ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB2017

    • Author(s)
      Yukari Okita, Minori Kimura, Rudy Xie, Chen Chen, Larina Tzu-Wei Shen, Yurika Kojima, Hiroyuki Suzuki, Masafumi Muratani, Masao Saitoh, Kentaro Semba, Carl-Henrik Heldin, Mitsuyasu Kato
    • Journal Title

      Science Signaling

      Volume: 10 Issue: 474 Pages: 11-11

    • DOI

      10.1126/scisignal.aak9397

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 乳がんにおけるGPNMBの役割2016

    • Author(s)
      沖田結花里、陳晨、鈴木裕之、加藤光保
    • Organizer
      第39回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 神奈川県 横浜市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Roles of GPNMB in Breast Cancer Stem Cells2016

    • Author(s)
      陳晨、沖田結花里、加藤光保
    • Organizer
      第39回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 神奈川県 横浜市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Roles of GPNMB in breast cancer malignant formation and progression2016

    • Author(s)
      Yukari Okita, Hiroyuki Suzuki, and Mitsuyasu Kato
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜 神奈川県 横浜市
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転写因子MafKはTGF-βによって誘導され、腫瘍形成を促進する2016

    • Author(s)
      加藤光保、沖田結花里
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜 神奈川県 横浜市
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Roles of GPNMB in breast cancer initiation and malignant progression2016

    • Author(s)
      Yukari Okita, Ai Kato, Chen Chen, Hiroyuki Suzuki, and Mitsuyasu Kato
    • Organizer
      the 41st Naito Conference
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ 北海道 札幌市
    • Year and Date
      2016-07-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳がんの発生・進展におけるGPNMBの役割2016

    • Author(s)
      沖田結花里、鈴木裕之、加藤光保
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター 宮城県 仙台市
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳がんの発生・進展におけるGPNMBの役割2016

    • Author(s)
      沖田結花里、鈴木裕之、加藤光保
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      宮城県仙台市、仙台国際交流センター
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 乳がんにおける転写因子MafKの働き2015

    • Author(s)
      沖田結花里、鈴木裕之、加藤光保
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市、名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Transcription factor MafK induces epithelial-mesenchymal transition and malignant progression of breast cancer cells2015

    • Author(s)
      Yukari Okita, Hiroyuki Suzuki, and Mitsuyasu Kato
    • Organizer
      FASEB meeting The TGF-β Superfamily: Signaling in Development and Disease
    • Place of Presentation
      アメリカ合衆国コロラド州
    • Year and Date
      2015-07-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 乳がんの腫瘍形成・転移形成における新たな仕組みの解明

    • URL

      http://www.tsukuba.ac.jp/attention-research/p201704120300.html

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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