Study on DNA editing enzymes leading EB virus infected epithelial cells to tumorigenesis
| Project/Area Number |
15K19113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | EBウイルス / 上皮性腫瘍 / APOBEC / ミトコンドリア / EBV / Gastric carcinoma / Mitochondria / mitchondria DNA |
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| Outline of Final Research Achievements |
The oncogenic contribution of EBV for gastric cancer and nasopharyngeal carcinoma is not fully elucidated. In this study, we focused on DNA-editing enzyme APOBEC and clarified that EBV-induced APOBEC3 damages mitochondrial DNA via C-to-T mutagenesis. Because mitochondrial DNA damage is found in many cancers and correlates with the prognosis of cancer patients, clarifying the molecular mechanism of APOBEC3 and mitochondrial DNA damage contributes to elucidation of tumorigenesis of EBV-infected epithelial cells and leads to the development of therapeutic drugs.
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Report
(3 results)
Research Products
(11 results)
