Induction of vaccine-elicited T cell responses by non-natural amino acids
| Project/Area Number |
15K19116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kyushu University (2016)
Kinki University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | T細胞 / ウイルス感染 / ペプチド免疫 / ペプチドワクチン / レトロウイルス |
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| Outline of Final Research Achievements |
Understanding functional characteristics of T-cell responses associated with effective elimination of pathogenic retroviruses or tumors is crucial for the development of vaccines. In this study, we demonstrated that the use of an appropriate epitope preferentially induces functional T cell responses in the early phase of acute retroviral infection that contribute to the effective antiviral protection, providing a better information for the development of vaccine.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.2016
Author(s)
Takamura, S., H. Yagi, Y. Hakata, C. Motozono, S. R. McMaster, T. Masumoto, M. Fujisawa, T. Chikaishi, J. Komeda, J. Itoh, M. Umemura, A. Kyusai, M. Tomura, T. Nakayama, D. L. Woodland, J. E. Kohlmeier, and M. Miyazawa
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Journal Title
The Journal of Experimental Medicine
Volume: 213
Issue: 13
Pages: 3057-3073
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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