Crosstalk between RNA silencing and antiviral response in mammalian cells
| Project/Area Number |
15K19124
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Takahashi Tomoko 東京大学, 大学院理学系研究科(理学部), 助教 (00738792)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | RNAサイレンシング / 抗ウイルス反応 / 抗ウイルス応答 |
|---|
| Outline of Final Research Achievements |
The siRNAs and miRNAs are small non-coding RNAs that mediate mRNA cleavage, degradation, and/or translational repression by a mechanism known as RNA silencing. RNA viruses infected into human cells are recognized by virus sensor proteins to activate interferon expression as an antiviral defense system. Here, we revealed that RNA silencing and antiviral defense system are mutually regulated by their components.
|
Report
(3 results)
Research Products
(22 results)
