Regulatory mechanisms of autoimmunity by LAG-3 expressing cells
Project/Area Number |
15K19132
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | The University of Tokushima |
Principal Investigator |
OKAZAKI Il-mi 徳島大学, 先端酵素学研究所(プロテオ), 准教授 (50452339)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 抑制性免疫補助受容体 / 単一細胞発現解析 / 自己免疫疾患 |
Outline of Final Research Achievements |
LAG-3 is an immuno-inhibitory receptor that plays a critical role in the prevention of autoimmunity. To understand cell population(s) and their role(s) on which LAG-3 functions in the regulation of autoimmunity, we analyzed LAG-3 expressing CD4 T cells by single-cell gene expression analysis. We found that LAG-3 expressing cells were clustered into distinct cell populations and identified unique cell populations that may function in the suppression of autoimmunity.
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Report
(3 results)
Research Products
(13 results)
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[Presentation] Comparison of human and mouse LAG-3.2015
Author(s)
KAJIHARA Takeo, SUGIURA Daisuke, MIZUNO Reina, RANAWAKAGE Chamila Deshani, MAEDA Natsumi, SHIMIZU Kenji, OKAZAKi Il-mi, OKAZAKI Taku
Organizer
The 44th annual meeting of the JSI
Place of Presentation
札幌コンベンションセンター(北海道・札幌市)
Year and Date
2015-11-18
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