Development of ultra-sensitive detection method not affected by oxidation / reduction substances in biological samples and verification of its development

Research Project

Project/Area Number	15K19182
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Laboratory medicine
Research Institution	Kyushu University
Principal Investigator	HOKAZONO EISAKU 九州大学, 医学研究院, 講師 (60404042)
Research Collaborator	OHSAWA Susumu KAYAMORI Yuzo SEIMIYA Masanori KAWANO Miki
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	高感度検出 / 錯体化学 / 過酸化水素 / 金属器レータ / 高感度化 / 金属キレータ
Outline of Final Research Achievements	We succeeded in finding combinations of dyes and metals for highly sensitive detection of hydrogen peroxide and optimum conditions for reacting them with higher sensitivity. However, the target measurement sensitivity was only 15 to 40 times the current detection technology, and it was not able to reach the target sensitivity of about 100 times. In the future, we will pursue further sensitivity and verify the usefulness and applicability of the high sensitivity detection technique of this method.

Report

(4 results)