Elucidation of acupuncture analgesia mechanism using multimodal noninvasive brain function measurement
| Project/Area Number |
15K19196
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Meiji University of Integrative Medicine |
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Principal Investigator |
Murase Tomokazu 明治国際医療大学, 医学教育研究センター, 客員助教 (00708943)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | fMRI / 鍼 / 体性感覚刺激 / 鍼灸 / 体性感覚 / MRS / MRI / 安静時脳活動 |
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| Outline of Final Research Achievements |
In this study, we aimed to evaluate the central nervous system evaluation index of the mind and body condition which is considered to be the cause of the individual difference of the acupunctrue analgesic effect by clinical experience.This study was conducted on healthy subjects using functional magnetic resonance imaging(fMRI). It was confirmed that manual acupuncture stimulation is delayed from the actual stimulus input time as compared with sponge abrasion stimulation and that long lasting brain activity is induced widely. It was suggested that the brain activation of the perceptual area is different depending on the subject at the time of palm scrub stimulation, and it is suggested that it may be a factor showing individual differences.
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| Academic Significance and Societal Importance of the Research Achievements |
鍼灸やスポンジ擦過などの体性感覚刺激に伴う脳活動の経時変化を調べる研究を行った結果、撚鍼刺激に伴う脳活動は、スポンジ擦過刺激のような触覚刺激とは違い、刺激中よりも刺激終了後の方が広い脳領域を賦活することが確認された。この刺激の種類による経時的変化の違いは fMRI の解析結果に大きな差を生むため、すでに行われている鍼刺激に関する実験モデルから新たな知見を得られる可能性も期待できる。
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Report
(5 results)
Research Products
(11 results)
