Mechanisms of pain sensation through interactions between TRP channels and anoctamin 1
Project/Area Number |
15K19197
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pain science
|
Research Institution | Okazaki Research Facilities, National Institutes of Natural Sciences |
Principal Investigator |
TAKAYAMA Yasunori 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 特任助教 (60711033)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | TRPV1 / アノクタミン1 / 疼痛 / 一次感覚神経 / 急性疼痛 |
Outline of Final Research Achievements |
TRPV1, a capsaicin receptor, is an important ion channel in sensory nerves to detect painful situation in skin. For long time, TRPV1 has been believed as main ion channel inducing burning pain, however we identified the interaction with anoctamin 1, a kind of chloride channel. This TRPV1-anoctamin 1 interaction is a molecular mechanism to enhance TRPV1-mediated pain sensation. In addition, capsaicin-induced pain was reduced by anoctamin 1 inhibitor. Thus, the painkiller targeting anoctamin 1 could be better therapy in clinical situations. Furthermore, we found a new chemical compound which has inhibitory effect on anoctamin 1 activity. Therefore, this chemical could be novel seeds in the development of painkiller.
|
Report
(3 results)
Research Products
(16 results)
-
-
-
[Journal Article] Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families2016
Author(s)
Okuda H, Noguchi A, Kobayashi H, Kondo D, Harada KH, Youssefian S, Shioi H, Kabata R, Domon Y, Kubota K, Kitano Y, Takayama Y, Hitomi T, Ohno K, Saito Y, Asano T, Tominaga M, Takahashi T, Koizumi A
-
Journal Title
Plos ONE
Volume: 11
Pages: e0154827
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue2016
Author(s)
Sun W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M
-
Journal Title
EMBO reports
Volume: 17
Pages: 383-99
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-