Development of deformable image registration-based dose accumulation between external beam radiotherapy and brachytherapy in cervical cancer patients

• Project/Area Number: 15K19199
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Tohoku University
• Principal Investigator: Kadoya Noriyuki 東北大学, 大学病院, 助教 (20604961)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 放射線治療 / 子宮頸癌 / 非剛体レジストレーション / 画像変形 / 合算線量 / RALS / 線量分布 / 小線源治療 / 線量合算 / 医学物理 / 非剛体位置照合 / ガラス線量計 / 非剛体位置合わせ

Outline of Final Research Achievements

In this study, we aim to develop deformable image registration (DIR) -based dose accumulation between external beam radiotherapy and brachytherapy in cervical cancer patients. First, deformable female pelvis phantom was created by the 3D printer. Then, DIR accuracies of two different DIR methods (intensity-based DIR and hybrid DIR) were evaluated using the deformable phantom. Finally, we clarified the accuracy of DIR-based dose accumulation using the two DIR methods, showing that hybrid DIR had the great potential for constructing the accurate DIR-based dose accumulation system.

Academic Significance and Societal Importance of the Research Achievements

本研究成果を実用化させることで、子宮頸がんの外部照射と腔内照射併用症例において、患者ごとに腫瘍および危険臓器への正確な線量を把握することができ、より患者に適したオーダーメードの放射線治療計画を立案することが可能となる。また、この技術を利用し、これまでに治療した症例の積算線量を解析することで、腫瘍への線量と治癒率、危険臓器への線量と障害発生率の関係も明らかにすることができ、子宮頸がんの放射線治療において非常に重要なデータを算出することができる。

Research Products

• [Journal Article] Impact of a commercially available model-based dose calculation algorithm on treatment planning of high-dose-rate brachytherapy in patients with cervical cancer (2018)
  • Author(s): Abe Kota、Kadoya Noriyuki、Sato Shinya、Hashimoto Shimpei、Nakajima Yujiro、Miyasaka Yuya、Ito Kengo、Umezawa Rei、Yamamoto Takaya、Takahashi Noriyoshi、Takeda Ken、Jingu Keiichi
  • Journal Title: Journal of Radiation Research Volume: 59 Issue: 2 Pages: 198-206
  • DOI: 10.1093/jrr/rrx081
  • Peer Reviewed
• [Journal Article] Evaluation of rectum and bladder dose accumulation from external beam radiotherapy and brachytherapy for cervical cancer using two different deformable image registration techniques (2017)
  • Author(s): Kadoya Noriyuki、Miyasaka YuYa、Yamamoto Takaya、Kuroda Yoshihiro、Ito Kengo、Chiba Mizuki、Nakajima Yujiro、Takahashi Noriyoshi、Kubozono Masaki、Umezawa Rei、Dobashi Suguru、Takeda Ken、Jingu Keiichi
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 5 Pages: 720-728
  • DOI: 10.1093/jrr/rrx028
  • Peer Reviewed
• [Journal Article] Evaluation of deformable image registration between external beam radiotherapy and HDR brachytherapy for cervical cancer with a 3D-printed deformable pelvis phantom (2017)
  • Author(s): Kadoya N, Miyasaka Y, Nakajima Y, Kuroda Y, Ito K, Chiba M, Sato K, Dobashi S, Yamamoto T, Takahashi N, Kubozono M, Takeda K, Jingu K.
  • Journal Title: Medical Physcis Volume: 印刷中 Issue: 4 Pages: 1445-1455
  • DOI: 10.1002/mp.12168
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation of the performance of deformable image registration between planning CT and CBCT images for the pelvic region: comparison between hybrid and intensity-based DIR. (2017)
  • Author(s): Takayama Y, Kadoya N, Yamamoto T, Ito K, Chiba M, Fujiwara K, Miyasaka Y, Dobashi S, Sato K, Takeda K, Jingu K.
  • Journal Title: Journal of Radiation Research Volume: 印刷中 Issue: 4 Pages: 567-571
  • DOI: 10.1093/jrr/rrw123
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Multi-institutional Validation Study of Commercially Available Deformable Image Registration Software for Thoracic Images. (2016)
  • Author(s): Kadoya N, Nakajima Y, Saito M, Miyabe Y, Kurooka M, Kito S, Fujita Y, Sasaki M, Arai K, Tani K, Yagi M, Wakita A, Tohyama N, Jingu K.
  • Journal Title: International Journal of Radiation Oncology*Biology* Physics Volume: 96 Pages: 422-431
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Novel dosimetric measurement using RGD for HDR Brachytherapy with 3D printed deformable female pelvis phantom (2017)
  • Author(s): Kota Abe, Noriyuki Kadoya, Shimpei Hashimoto, Yuya Miyasaka,Yujiro Nakajima, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Ken Takeda, Keiichi Jingu
  • Organizer: 第113回日本医学物理学会学術大会
• [Presentation] Feasibility of a novel evaluation method for deformable image registration-based dose accumulation for HDR brachytherapy with a deformable phantom (2017)
  • Author(s): Kota Abe, Noriyuki Kadoya, Shimpei Hashimoto, Yuya Miyasaka,Yujiro Nakajima, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Ken Takeda, Keiichi Jingu
  • Organizer: 第59回米国医学物理学会学術大会
  • Int'l Joint Research
• [Presentation] Multi-institutional validation study of commercially available deformable image registration software for thoracic images (2016)
  • Author(s): Kadoya N, Nakajima Y, Saito M, Miyabe Y, Kurooka M, Kito S, Sasaki M, Fujita Y, Arai K, Tani K, Yagi M, Wakita A, Tohyama N, Jingu K
  • Organizer: 第29回日本放射線腫瘍学会学術大会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2016-11-25
• [Presentation] Deformable image registration accuracy between external beam radiotherapy and HDR brachytherapy CT images for cervical cancer using a 3D-printed deformable pelvis phantom (2016)
  • Author(s): Miyasaka Y, Kadoya N, Kuroda Y, Ito K, Chiba M, Nakajima Y, Sato K, Dobashi S, Takeda K, Jingu K
  • Organizer: 第58回米国医学物理学会学術大会
  • Place of Presentation: ワシントン (米国)
  • Year and Date: 2016-07-31
  • Int'l Joint Research
• [Presentation] Multi-institutional validation study of commercially available deformable image registration software for thoracic images (2016)
  • Author(s): Kadoya N, Nakajima Y, Saito M, Miyabe Y, Kurooka M, Kito S, Sasaki M, Fujita Y, Arai K, Tani K, Yagi M, Wakita A, Tohyama N, Jingu K
  • Organizer: 第58回米国医学物理学会学術大会
  • Place of Presentation: ワシントン (米国)
  • Year and Date: 2016-07-31
  • Int'l Joint Research
• [Presentation] Development of a deformable woman’s pelvis phantom with physiological characteristics for evaluation of DIR accuracy using 3D-printer (2016)
  • Author(s): Yuya Miyasaka, Noriyuki Kadoya, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Yujiro Nakajima, Kiyokazu Sato, Suguru Dobashi, Ken Takeda and Keiichi Jingu
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2016-04-14
• [Presentation] Development of a deformable woman’s pelvis phantom with physiological characteristics for evaluation of DIR accuracy using 3D-printer (2016)
  • Author(s): Miyasaka Y, Kadoya N, Kuroda Y, Ito K, Chiba M, Nakajima Y, Sato K, Dobashi S, Takeda K, Jingu K
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-04-13
• [Presentation] 外照射併用IGBTにおける積算線量評価システムの構築 (2015)
  • Author(s): 角谷倫之、宮坂友侑也、山本貴也、神宮啓一
  • Organizer: マイクロセレクトロンHDR研究会
  • Place of Presentation: コクヨホール(東京)
  • Year and Date: 2015-12-05
  • Invited
• [Remarks] 研究紹介
  • URL: http://www.radiol.med.tohoku.ac.jp/medical-physics/research.html