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Development of deformable image registration-based dose accumulation between external beam radiotherapy and brachytherapy in cervical cancer patients

Research Project

Project/Area Number 15K19199
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionTohoku University

Principal Investigator

Kadoya Noriyuki  東北大学, 大学病院, 助教 (20604961)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords放射線治療 / 子宮頸癌 / 非剛体レジストレーション / 画像変形 / 合算線量 / RALS / 線量分布 / 小線源治療 / 線量合算 / 医学物理 / 非剛体位置照合 / ガラス線量計 / 非剛体位置合わせ
Outline of Final Research Achievements

In this study, we aim to develop deformable image registration (DIR) -based dose accumulation between external beam radiotherapy and brachytherapy in cervical cancer patients. First, deformable female pelvis phantom was created by the 3D printer. Then, DIR accuracies of two different DIR methods (intensity-based DIR and hybrid DIR) were evaluated using the deformable phantom. Finally, we clarified the accuracy of DIR-based dose accumulation using the two DIR methods, showing that hybrid DIR had the great potential for constructing the accurate DIR-based dose accumulation system.

Academic Significance and Societal Importance of the Research Achievements

本研究成果を実用化させることで、子宮頸がんの外部照射と腔内照射併用症例において、患者ごとに腫瘍および危険臓器への正確な線量を把握することができ、より患者に適したオーダーメードの放射線治療計画を立案することが可能となる。また、この技術を利用し、これまでに治療した症例の積算線量を解析することで、腫瘍への線量と治癒率、危険臓器への線量と障害発生率の関係も明らかにすることができ、子宮頸がんの放射線治療において非常に重要なデータを算出することができる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Impact of a commercially available model-based dose calculation algorithm on treatment planning of high-dose-rate brachytherapy in patients with cervical cancer2018

    • Author(s)
      Abe Kota、Kadoya Noriyuki、Sato Shinya、Hashimoto Shimpei、Nakajima Yujiro、Miyasaka Yuya、Ito Kengo、Umezawa Rei、Yamamoto Takaya、Takahashi Noriyoshi、Takeda Ken、Jingu Keiichi
    • Journal Title

      Journal of Radiation Research

      Volume: 59 Issue: 2 Pages: 198-206

    • DOI

      10.1093/jrr/rrx081

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of rectum and bladder dose accumulation from external beam radiotherapy and brachytherapy for cervical cancer using two different deformable image registration techniques2017

    • Author(s)
      Kadoya Noriyuki、Miyasaka YuYa、Yamamoto Takaya、Kuroda Yoshihiro、Ito Kengo、Chiba Mizuki、Nakajima Yujiro、Takahashi Noriyoshi、Kubozono Masaki、Umezawa Rei、Dobashi Suguru、Takeda Ken、Jingu Keiichi
    • Journal Title

      Journal of Radiation Research

      Volume: 58 Issue: 5 Pages: 720-728

    • DOI

      10.1093/jrr/rrx028

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of deformable image registration between external beam radiotherapy and HDR brachytherapy for cervical cancer with a 3D-printed deformable pelvis phantom2017

    • Author(s)
      Kadoya N, Miyasaka Y, Nakajima Y, Kuroda Y, Ito K, Chiba M, Sato K, Dobashi S, Yamamoto T, Takahashi N, Kubozono M, Takeda K, Jingu K.
    • Journal Title

      Medical Physcis

      Volume: 印刷中 Issue: 4 Pages: 1445-1455

    • DOI

      10.1002/mp.12168

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of the performance of deformable image registration between planning CT and CBCT images for the pelvic region: comparison between hybrid and intensity-based DIR.2017

    • Author(s)
      Takayama Y, Kadoya N, Yamamoto T, Ito K, Chiba M, Fujiwara K, Miyasaka Y, Dobashi S, Sato K, Takeda K, Jingu K.
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中 Issue: 4 Pages: 567-571

    • DOI

      10.1093/jrr/rrw123

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multi-institutional Validation Study of Commercially Available Deformable Image Registration Software for Thoracic Images.2016

    • Author(s)
      Kadoya N, Nakajima Y, Saito M, Miyabe Y, Kurooka M, Kito S, Fujita Y, Sasaki M, Arai K, Tani K, Yagi M, Wakita A, Tohyama N, Jingu K.
    • Journal Title

      International Journal of Radiation Oncology*Biology* Physics

      Volume: 96 Pages: 422-431

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Novel dosimetric measurement using RGD for HDR Brachytherapy with 3D printed deformable female pelvis phantom2017

    • Author(s)
      Kota Abe, Noriyuki Kadoya, Shimpei Hashimoto, Yuya Miyasaka,Yujiro Nakajima, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Ken Takeda, Keiichi Jingu
    • Organizer
      第113回日本医学物理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feasibility of a novel evaluation method for deformable image registration-based dose accumulation for HDR brachytherapy with a deformable phantom2017

    • Author(s)
      Kota Abe, Noriyuki Kadoya, Shimpei Hashimoto, Yuya Miyasaka,Yujiro Nakajima, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Ken Takeda, Keiichi Jingu
    • Organizer
      第59回米国医学物理学会学術大会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multi-institutional validation study of commercially available deformable image registration software for thoracic images2016

    • Author(s)
      Kadoya N, Nakajima Y, Saito M, Miyabe Y, Kurooka M, Kito S, Sasaki M, Fujita Y, Arai K, Tani K, Yagi M, Wakita A, Tohyama N, Jingu K
    • Organizer
      第29回日本放射線腫瘍学会学術大会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Deformable image registration accuracy between external beam radiotherapy and HDR brachytherapy CT images for cervical cancer using a 3D-printed deformable pelvis phantom2016

    • Author(s)
      Miyasaka Y, Kadoya N, Kuroda Y, Ito K, Chiba M, Nakajima Y, Sato K, Dobashi S, Takeda K, Jingu K
    • Organizer
      第58回米国医学物理学会学術大会
    • Place of Presentation
      ワシントン (米国)
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multi-institutional validation study of commercially available deformable image registration software for thoracic images2016

    • Author(s)
      Kadoya N, Nakajima Y, Saito M, Miyabe Y, Kurooka M, Kito S, Sasaki M, Fujita Y, Arai K, Tani K, Yagi M, Wakita A, Tohyama N, Jingu K
    • Organizer
      第58回米国医学物理学会学術大会
    • Place of Presentation
      ワシントン (米国)
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a deformable woman’s pelvis phantom with physiological characteristics for evaluation of DIR accuracy using 3D-printer2016

    • Author(s)
      Yuya Miyasaka, Noriyuki Kadoya, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Yujiro Nakajima, Kiyokazu Sato, Suguru Dobashi, Ken Takeda and Keiichi Jingu
    • Organizer
      第111回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-04-14
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of a deformable woman’s pelvis phantom with physiological characteristics for evaluation of DIR accuracy using 3D-printer2016

    • Author(s)
      Miyasaka Y, Kadoya N, Kuroda Y, Ito K, Chiba M, Nakajima Y, Sato K, Dobashi S, Takeda K, Jingu K
    • Organizer
      第111回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-04-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 外照射併用IGBTにおける積算線量評価システムの構築2015

    • Author(s)
      角谷倫之、宮坂友侑也、山本貴也、神宮啓一
    • Organizer
      マイクロセレクトロンHDR研究会
    • Place of Presentation
      コクヨホール(東京)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Remarks] 研究紹介

    • URL

      http://www.radiol.med.tohoku.ac.jp/medical-physics/research.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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