| Project/Area Number |
15K19364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TAJIRI Kazuko 筑波大学, 医学医療系, 助教 (60633914)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 心筋梗塞 / リモデリング / 好中球 / 好中球細胞外トラップ / 好中球エラスターゼ / 心筋リモデリング |
|---|
| Outline of Final Research Achievements |
Neutrophil forms neutrophil extracellular traps (NETs), in which bacteria is effectively trapped and eliminated. The role of NETs in the pathogenesis of acute myocardial infarction (AMI), a representative of non-infectious inflammation, is unclear. We analyzed the inflammatory responses induced by AMI in neutrophil elastase gene knockout mice, in which NETs formation is impaired. The knockout mice showed the reduced death due to cardiac rupture and higher survival. The profile of cytokine alteration showed the anti-inflammatory responses. Therefore, the presence of NETs is suggested to be pro-inflammatory and to promote the pathogenesis of AMI.
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