Research Project
Grant-in-Aid for Young Scientists (B)
The purpose of this study is to elucidate the role of C type natriuretic peptide(CNP) secreted from cardiac myofibroblast on cardiac remodeling and the molecular mechanism involved in it by using cardiac constituent cell specific CNP or GC-B knockout mice, and is to clarify the significance of CNP on prevention of cardiac hypertrophy and heart failure. In this study, cardiac hypertrophy due to pressure overload exacerbated in myofibroblast-specific CNP knockout mice compared with control mice. These data suggested that the myofibroblast-derived CNP plays a protective role in pathological myocardial remodeling.
All 2017 2016 2015 Other
All Journal Article (3 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 3 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (3 results) Remarks (1 results)
Hypertension
Volume: 69 Pages: 289-296
Cardiovascular Research
Volume: 109 Issue: 1 Pages: 162-173
10.1093/cvr/cvv248
Am J Physiol Regul Integr Comp Physiol.
Volume: 309 Issue: 6 Pages: R639-R649
10.1152/ajpregu.00074.2015
http://kyoto-u-cardio.jp/kisokenkyu/cat236/