| Project/Area Number |
15K19383
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
Saku Keita 九州大学, 循環器病未来医療研究センター, 助教 (40567385)
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| Research Collaborator |
FUJII Kana
OGA Yasuhiro
SHINODA Masako
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自律神経 / 末梢化学受容器反射 / 慢性心不全 / 心筋梗塞 / 高血圧 |
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| Outline of Final Research Achievements |
Carotid body denervation (CBD) has shown to reduce sympathetic nerve activity (SNA) in several cardiovascular animal models. We examined if CBD prevents worsening of cardiac function and heart failure (HF) via sympatho-inhibitory effect in rat models of myocardial infarction (MI) and hypertension (HTN), which are the two major cause of secondary HF. In both MI and HTN, CBD significantly reduced plasma norepinephrine (NE), an index of sympathetic drive. CBD preserved LV ejection fraction and lowered LV end-diastolic pressure. In MI group, CBD reduced the number of inflammatory macrophages in the LV and the plasma concentration of interleukin-1β, indicating the anti-inflammatory response. In HTN groups, CBD significantly reduced blood pressure and markedly improved the survival rate with relative risk reduction 64.8%. CBD prevents the worsening of cardiac function and heart failure in rat models of HF. CBD can be the one of neuro-modulatory treatments for secondary HF.
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