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Emerging diagnostic methods and risk stratification for cardiac sarcoidosis

Research Project

Project/Area Number 15K19402
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionHokkaido University (2017)
National Cardiovascular Center Research Institute (2015-2016)

Principal Investigator

Nagai Toshiyuki  北海道大学, 大学病院, 助教 (00528218)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心臓サルコイドーシス / 免疫応答 / マクロファージ / 樹状細胞 / 病理組織診断
Outline of Final Research Achievements

The numbers of dendritic cells (DC) and macrophages were investigated in 95 consecutive cardiac sarcoidosis (CS) patients and 50 patients with nonischemic cardiomyopathy as controls. In CS patients with and without myocardial granulomas, CD209+ DC and CD68+ macrophages were more frequently observed (P<0.01) and CD163+M2 macrophages were less frequently observed (P<0.01) in nongranuloma sections compared to controls. Furthermore, the combination of decreased CD163+M2/CD68+ macrophage ratio and increased number of CD209+ DC in nongranuloma sections of CS patients demonstrated high specificity (100%, 95% CI 92.7-100%) for CS diagnosis with each diagnostic criteria and the presence of myocardial granulomas. In conclusions, increased number of DC and decreased M2 among all macrophages in nongranuloma sections of myocardium showed high specificity for CS diagnosis, suggesting DC and macrophage phenotypes as histopathological surrogates for the diagnosis of CS.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 3 results)

  • [Journal Article] Myocardial Immunocompetent Cells and Macrophage Phenotypes as Histopathological Surrogates for Diagnosis of Cardiac Sarcoidosis in Japanese.2016

    • Author(s)
      Honda Y, Nagai T, Ikeda Y, Sakakibara M, Asakawa N, Nagano N, Nakai M, Nishimura K, Sugano Y, Ohta-Ogo K, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Tsutsui H, Ishibashi-Ueda H, Anzai T.
    • Journal Title

      Journal of the American Heart Association

      Volume: 5 Issue: 11

    • DOI

      10.1161/jaha.116.004019

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Discontinuation of Prednisolone Therapy on Risk of Cardiac Mortality Associated with Worsening Left Ventricular Dysfunction in Cardiac Sarcoidosis.2016

    • Author(s)
      Nagai T, Nagano N, Sugano Y, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Ogawa H, Anzai T.
    • Journal Title

      American Journal of Cardiology

      Volume: 117 Issue: 6 Pages: 966-71

    • DOI

      10.1016/j.amjcard.2015.12.033

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Usefulness of Dendritic Cells and Macrophage Phenotypes Infiltrated Into Myocardium for Diagnosis of Cardiac Sarcoidosis2016

    • Author(s)
      Nagai T, Honda Y, Ikeda Y, Sakakibara M, Asakawa N, Nagano N, Yasuda S, Tsutsui H, Ueda HI, Anzai T
    • Organizer
      第20回日本心不全学会学術集会
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 心臓サルコイドーシスにおけるステロイド療法の現状と今後の課題.2016

    • Author(s)
      永井利幸,永野伸卓,菅野康夫,浅海泰栄,草野研吾,野口暉夫,安田聡,安斉俊久
    • Organizer
      第64回日本心臓病学会学術集会
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Corticosteriod Therapy for Cardiac Sarcoidosis2016

    • Author(s)
      Nagai T, Nagano N, Kusano K, Yasuda S, Anzai T.
    • Organizer
      第63回日本不整脈心電学会学術集会
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 心臓サルコイドーシスにおけるステロイド治療~開始と中止の至適タイミングをどのように考えるべきか~2016

    • Author(s)
      永井利幸,永野伸卓,菅野康夫,浅海泰栄,草野研吾,野口暉夫,安田聡,安斉俊久.
    • Organizer
      第2回日本心筋症研究会
    • Place of Presentation
      Matsumoto
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 心臓サルコイドーシスにおけるステロイド治療の途中中止は左室機能障害の進行と関連して心臓死を増加させる.2015

    • Author(s)
      永井利幸,永野伸卓, 菅野康夫, 相庭武司, 神崎秀明, 草野研吾, 野口輝夫, 安田聡, 小 川久雄, 安斉俊久.
    • Organizer
      第35回日本サルコイドーシス/肉芽腫性疾患学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] Discontinuation of Corticosteroid Therapy Increases the Risk of Cardiac Mortality Associated with Progression of Left Ventricular Dysfunction in Cardiac Sarcoidosis.2015

    • Author(s)
      Nagai T, Nagano N, Sugano Y, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Ogawa H, Anzai T.
    • Organizer
      第19回日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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