Identification of exosomal microRNA associated with severe obstructive lung diseases and its clinical application
| Project/Area Number |
15K19405
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
Suzuki Masaru 北海道大学, 大学病院, 助教 (10374290)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | エクソソーム / microRNA / 難治性喘息 |
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| Outline of Final Research Achievements |
Serum exosomal RNA profiles were altered in patients with severe asthma compared with healthy volunteers and patients with mild-to-moderate asthma. MicroRNA analysis revealed that four microRNAs were significantly up-regulated in patients with severe asthma, and pathway analysis identified ErbB signaling pathway and Neurotrophin signaling pathway as top-ranked pathways regulated by the up-regulated microRNAs.
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Report
(3 results)
Research Products
(2 results)
