Identification of exosomal microRNA associated with severe obstructive lung diseases and its clinical application

Research Project

Project/Area Number	15K19405
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Respiratory organ internal medicine
Research Institution	Hokkaido University
Principal Investigator	Suzuki Masaru 北海道大学, 大学病院, 助教 (10374290)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	エクソソーム / microRNA / 難治性喘息
Outline of Final Research Achievements	Serum exosomal RNA profiles were altered in patients with severe asthma compared with healthy volunteers and patients with mild-to-moderate asthma. MicroRNA analysis revealed that four microRNAs were significantly up-regulated in patients with severe asthma, and pathway analysis identified ErbB signaling pathway and Neurotrophin signaling pathway as top-ranked pathways regulated by the up-regulated microRNAs.

Report

(3 results)