| Project/Area Number |
15K19423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
HARA Atsuko 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70736420)
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| Research Collaborator |
NAKASHIMA Shota
HARADA Tatsuhiko
TOMONAGA Masaomi
YURA Hirokazu
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 夏型過敏性肺炎 / Human Apolipoprotein E / イムノコンプレキソーム解析法 / 気管支肺胞洗浄 / 過敏性肺炎 / 免疫複合体 / 網羅的解析 |
|---|
| Outline of Final Research Achievements |
This study aimed to identify the antigens of hypersensitivity pneumonia by immune complexome analysis. Immune complexome analysis revealed Human Apolipoprotein E was frequently detected in bronchoalveolar lavage fluid in patients with summer type hypersensitivity pneumonia compared with disease controls. Furthermore, Human Apolipoprotein E levels in bronchoalveolar lavage fluid elevated compared with disease controls and were associated with clinical parameters in patients with summer type hypersensitivity pneumonia. These results suggest that Human Apolipoprotein E play a role in the pathogenesis of summer type hypersensitivity pneumonia.
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