2017 Fiscal Year Final Research Report
Immune complexome analysis in patients with hypersensitivity pneumonia
Project/Area Number |
15K19423
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | Nagasaki University |
Principal Investigator |
HARA Atsuko 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70736420)
|
Research Collaborator |
NAKASHIMA Shota
HARADA Tatsuhiko
TOMONAGA Masaomi
YURA Hirokazu
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 夏型過敏性肺炎 / Human Apolipoprotein E / イムノコンプレキソーム解析法 / 気管支肺胞洗浄 |
Outline of Final Research Achievements |
This study aimed to identify the antigens of hypersensitivity pneumonia by immune complexome analysis. Immune complexome analysis revealed Human Apolipoprotein E was frequently detected in bronchoalveolar lavage fluid in patients with summer type hypersensitivity pneumonia compared with disease controls. Furthermore, Human Apolipoprotein E levels in bronchoalveolar lavage fluid elevated compared with disease controls and were associated with clinical parameters in patients with summer type hypersensitivity pneumonia. These results suggest that Human Apolipoprotein E play a role in the pathogenesis of summer type hypersensitivity pneumonia.
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Free Research Field |
呼吸器内科学
|