Immune complexome analysis in patients with hypersensitivity pneumonia
Project/Area Number |
15K19423
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | Nagasaki University |
Principal Investigator |
HARA Atsuko 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70736420)
|
Research Collaborator |
NAKASHIMA Shota
HARADA Tatsuhiko
TOMONAGA Masaomi
YURA Hirokazu
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 夏型過敏性肺炎 / Human Apolipoprotein E / イムノコンプレキソーム解析法 / 気管支肺胞洗浄 / 過敏性肺炎 / 免疫複合体 / 網羅的解析 |
Outline of Final Research Achievements |
This study aimed to identify the antigens of hypersensitivity pneumonia by immune complexome analysis. Immune complexome analysis revealed Human Apolipoprotein E was frequently detected in bronchoalveolar lavage fluid in patients with summer type hypersensitivity pneumonia compared with disease controls. Furthermore, Human Apolipoprotein E levels in bronchoalveolar lavage fluid elevated compared with disease controls and were associated with clinical parameters in patients with summer type hypersensitivity pneumonia. These results suggest that Human Apolipoprotein E play a role in the pathogenesis of summer type hypersensitivity pneumonia.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] 特発性間質性肺炎における抗Ro-52抗体陽性症例の検討2017
Author(s)
石本裕士, 由良博一, 花香哲也, 伊藤千与, 小田桂士, 原 敦子, 角川智之, 城戸貴志, 坂本憲穂, 石松祐二, 矢寺和博, 佐藤 実, 迎 寛
Organizer
第57回日本呼吸器学会・学術講演会
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[Presentation] 特発性間質性肺炎症例における抗ARS抗体の臨床的意義の検討2017
Author(s)
由良博一, 中島章太, 原 敦子, 角川智之, 石本裕士, 坂本憲穂, 小田桂士, 城戸貴志, 矢寺和博, 佐藤 実, 迎 寛
Organizer
第57回日本呼吸器学会・学術講演会
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[Presentation] 過敏性肺炎患者気管支肺胞洗浄液における免疫複合体の検討2017
Author(s)
原 敦子, 由良博一, 中島章太, 角川智之, 石本裕士, 城戸貴志, 坂本憲穂, 松元信弘, 石井 寛, 矢寺和博, 石松祐二, 迎 寛
Organizer
第40回日本呼吸器内視鏡学会学術集会
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