Exploratory research of adipocyte related pulmonary cachectic factor and investigation of ghrelin's effect on cachexia
Project/Area Number |
15K19424
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | University of Miyazaki |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 悪液質 / グレリン / 肺癌 / ブレオマイシン / 脂肪細胞 / 肺線維症 |
Outline of Final Research Achievements |
Pulmonary cachexia is a frequent complication in patients with respiratory failure, such as lung cancer or COPD. The key features of cachexia are reductions in body weight and skeletal muscle mass. The development of therapeutic strategies for cachectic conditions are needed in patients with these respiratory diseases. Compared with the control mice, the pulmonary cachexia model mice had higher expression level of UCP1 in white adipose tissue, lower expression level of ghrelin in plasma and stomach, and lower activity of AgRP/NPY signaling in hypothalamus. In addition, treatment with ghrelin did not affect cell viability or proliferation in human lung adenocarcinoma cell line.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice2016
Author(s)
Naznin F, Sakoda H, Okada T, Tsubouchi H, Waise TM, Arakawa K, Nakazato M
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Journal Title
Eur J Pharmacol
Volume: 794
Pages: 37-44
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 医学のあゆみ2016
Author(s)
坪内拡伸、柳重久、中里雅光
Total Pages
6
Publisher
医歯薬出版株式会社
Related Report