| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Idiopathic pulmonary fibrosis is a poor prognosis lung fibrosis with a lot of active fibrotic lesions (i.e., fibroblastic foci). Fibroblasts in fibroblastic foci produced a large amount of extracellular matrix and leaded the destruction of lung architecture. Extracellular matrix acted as not only supporting material of tissues, but also regulatory factor of cellular function thorough receptors for extracellular matrix. This study showed that fibroblasts secreted type IV collagen in fibroblastic foci of idiopathic pulmonary fibrosis. Type IV collagen decreased the migration of lung fibroblasts and angiogenesis. These functions of type IV collagen were consistent with morphological characteristics of fibroblastic lesions such as poor vascularization and with the persistence of progressive fibrosis of idiopathic pulmonary fibrosis. Type IV collagen may be a prognosis prediction of idiopathic pulmonary fibrosis and a new therapeutic target of lung fibrosis.
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