Analysis of predisposing factors on early fibrotic focus in interstitial pneumonia using microdissection
Project/Area Number |
15K19434
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 間質性肺炎 / 細胞外基質 / 線維芽細胞 / IV型コラーゲン / ミクロダイセクション / 免疫組織化学 / 肺線維症 / 質量分析 / 通常型間質性肺炎 / 器質化肺炎 / キャンスタチン |
Outline of Final Research Achievements |
Idiopathic pulmonary fibrosis is a poor prognosis lung fibrosis with a lot of active fibrotic lesions (i.e., fibroblastic foci). Fibroblasts in fibroblastic foci produced a large amount of extracellular matrix and leaded the destruction of lung architecture. Extracellular matrix acted as not only supporting material of tissues, but also regulatory factor of cellular function thorough receptors for extracellular matrix. This study showed that fibroblasts secreted type IV collagen in fibroblastic foci of idiopathic pulmonary fibrosis. Type IV collagen decreased the migration of lung fibroblasts and angiogenesis. These functions of type IV collagen were consistent with morphological characteristics of fibroblastic lesions such as poor vascularization and with the persistence of progressive fibrosis of idiopathic pulmonary fibrosis. Type IV collagen may be a prognosis prediction of idiopathic pulmonary fibrosis and a new therapeutic target of lung fibrosis.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Role of canstatin in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts2016
Author(s)
Hirokazu Urushiyama, Yasuhiro Terasaki , Shinya Nagasaka , Nariaki Kokuho , Mika Terasaki , Shinobu Kunugi , Yu Mikami , Satoshi Noguchi , Masafumi Horie , Kiyotaka Nagahama , Yasuhiro Yamauchi , Akira Shimizu , Takahide Nagase
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Journal Title
International Journal of Clinical and Experimental Pathology
Volume: 9
Pages: 12714-12722
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] A selective α1 adrenoceptor antagonist, inhibits the growth of lung fibroblasts and attenuates bleomycin-induced lung fibrosis in mice2017
Author(s)
H. Urushiyama, Y. Terasaki, S. Nagasaka, N. Kokuho, S. Kunugi, H. Matsuzaki, Y. Hiraishi, Y. Mikami, S. Noguchi, M. Horie, Y. Yamauchi, T. Nagase
Organizer
EUROPEAN RESPIRATORY SOCIETY INTERNATIONAL CONGRESS 2017
Related Report
Int'l Joint Research
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