| Project/Area Number |
15K19435
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性閉塞性肺疾患 / マクロファージ / M2マクロファージ / COPDマウスモデル |
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| Outline of Final Research Achievements |
M2 macrophage is known to play important roles of chronic inflammation. In this study, we evaluated the roles of M2 macrophage in chronic obstructive pulmonary disease (COPD). We made COPD mice model by intratracheal administration of porcine pancreatic elastase (PPE). Although we obtained the lungs at 7, 14, 21 and 35 days after PPE administration and performed immunohistochemical staining, very few inflammatory cells were observed in the lungs. Next wild type mice and CD163 knockout mice were given PPE intratracheally and induced pulmonary emphysema. We analyzed at 21 days after treatment, the degree of emphysema was not difference between wild type mice and CD163 knockout mice.
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