The role of miRNA in airway epitherial cells
Project/Area Number |
15K19439
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | National Center for Child Health and Development |
Principal Investigator |
Igarashi Arisa 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, (非)研究員 (60572998)
|
Research Collaborator |
OKAMURA Kohji
MATSUDA Akio
MATSUMOTO Kenji
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | microRNA / 上皮細胞 / 喘息 / miR-29 / sST2 / IL33 / miRNA / アレルギー / 自然免疫 / ぜんそく |
Outline of Final Research Achievements |
To identify miRNAs that regulate expression of IL-33, an important cytokine gene for asthma development, expression of miRNAs in human airway epithelial cells was investigated. Consequently, although a novel miRNA directly controlling IL-33 expression could not be identified, miR-29 was found to regulate epithelial expression of both soluble ST2 (sST2), a decoy receptor for IL-33, and IFNAR1, a type 1 interferon receptor. Furthermore, I found that miR-29 is produced extracellularly via exosomes secreted by airway epithelial cells. These results suggest that miR-29 may be involved in the IL-33-dependent molecular mechanisms of asthma development, triggered by respiratory viral infection, via regulation of sST2 and IFNAR1 expression in the airway epithelial cells.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation.2016
Author(s)
Takeda T, Unno H, Morita H, Futamura K, Emi-Sugie M, Arae K, Shoda T, Okada N, Igarashi A, Inoue E, Kitazawa H, Nakae S, Saito H, Matsumoto K, Matsuda A.
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Journal Title
The Journal of Allergy and Clinical Immunology
Volume: in press
Pages: in press
DOI
Related Report
Peer Reviewed
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[Journal Article] Conditional deletion of CD98hc inhibits osteoclast development2016
Author(s)
Hideki Tsumura, Morihiro Ito, Masamichi Takami, Miyuki Arai, Xiao-Kang Li, Toshio Hamatani, Arisa Igarashi, Shuji Takada, Kenji Miyado, Akihiro Umezawa, Yasuhiko Ito
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Journal Title
Biochemistry and Biophysics Reports
Volume: 5
Pages: 203-210
DOI
Related Report
Peer Reviewed
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[Journal Article] Testicular dysgenesis/regression without campomelic dysplasia in patients carrying missense mutations and upstream deletion of SOX92015
Author(s)
Yuko Katoh-Fukui, Maki Igarashi, Keisuke Nagasaki, Reiko Horikawa, Toshiro Nagai, Takayoshi Tsuchiya, Erina Suzuki, Mami Miyado, Kenichiro Hata, Kazuhiko Nakabayashi, Keiko Hayashi, Yoichi Matsubara, Takashi Baba, Ken-ichirou Morohashi, Arisa Igarashi, Tsutomu Ogata, Shuji Takada & Maki Fukami
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Journal Title
Molecular Genetics & Genomic Medicine
Volume: 3
Pages: 550-557
DOI
Related Report
Peer Reviewed / Open Access
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