| Project/Area Number |
15K19473
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アストロサイト / 脱髄 / 視神経脊髄炎 / アクアポリン４ / 炎症性サイトカイン / 虚血性組織障害 / 多発性硬化症 / NMOモデルの確立 / 二次性脱髄機序の解明 |
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| Outline of Final Research Achievements |
In this study, we focused on two types of different pathology related to astrocytes injury. One is the effect on the myelin sheath caused by destruction and disappearance of astrocytes which typified by neuromyelitis optica spectrum disorders (NMOSD), and the other is a tissue dammage caused by reactive astrocytes seen in multiple sclerosis and other inflammatory demyelinating disease. As a result, the influence of astrocyte destruction itself is limited. On the other hand, we found inflammatory cytokines produced by reactive astrocytes exhibit a special pattern of myelin sheath damage.
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