| Project/Area Number |
15K19529
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Nobuaki Ito 東京大学, 医学部附属病院, 助教 (10731862)
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| Research Collaborator |
Fukumoto Seiji 徳島大学, 藤井節郎記念医科学センター, 特任教授
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 低リン血症 / FGF23 / Klotho / くる病 / 骨軟化症 / 腫瘍随伴症候群 / 免疫染色 / ナノ技術 / リン / カルシウム / ビタミンD / 傍腫瘍症候群 / 骨 / 受容体 |
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| Outline of Final Research Achievements |
To date, FGF23 was identified as the phosphate regulating humoral factor from the neoplasm causing tumor induced osteomalacia (TIO) by our study group. Then, FGFR1/Klotho complex was identified as the receptor complex for FGF23. In the current study, we are aiming to identify the phosphate sensing receptor also from the FGF23 producing tumor causing TIO. First, a nano imaging immunohistochemical technique for FGF23 was developed to detect very tiny amount of FGF23 because the expression level of FGF23 protein in a cell is fundamentally very low. This technique enables us to discriminate the FGF23 producing cells from the other type of cells in the same tumor. Hereafter, we will try to identify the phosphate sensing receptor through this technique.
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