| Project/Area Number |
15K19536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
TAMURA Kouichi 横浜市立大学, 医学部, 教授 (40285143)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 認知症 / 高血圧 / 循環器・高血圧 / 脳・神経 / レニン-アンジオテンシン系 / 中枢神経系 |
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| Outline of Final Research Achievements |
We used Spontanously Hypertensive Rats (SHR) and angiotensin II-infused Wister Rats as hypertension/cognitive impairment model animals. We examined the regulation of central nerve ATRAP expression in the onset and development of hypertension and cognitive impairment. Compared with control rats, SHR and angiotensin II-infused rats exhibited the increase in oxidative stress in SFO and PVN, concomitant with a decrease in ATRAP/AT1 receptor ratio. These results indicate that down-regulation of ATRAP/AT1 receptor in SFO and PVN is involved in the onset and development of hypertension and cognitive impairment.
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