Investigation of novel differentiation of megakaryocyte and its application in the mouse model
Project/Area Number |
15K19542
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | University of Tsukuba |
Principal Investigator |
KURITA Naoki 筑波大学, 医学医療系, 講師 (30555561)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 巨核球前駆細胞 / 臍帯血骨髄内移植 |
Outline of Final Research Achievements |
Gene expression at single cell level was analyzed with megakaryocytic progenitors extracted from human cord blood. The expression of megakaryocyte-related genes such as cMpl, GPIba, and vWF was observed, which is similar to the expression of the megakaryocytic progenitor that we previously found in mice. Intrabone-marrow transplantation of cord blood was performed with 15 adult cases with hematological malignancies. Platelet recovery was seen in 13 cases, which was superior to that of intravenous cord-blood transplantation. On-site hematopoiesis was enhanced after intrabone-marrow transplantation. These results suggest that megakaryocytic progenitors of cord blood which engraft at the local site contribute to platelet production after transplantation.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] A phase I/II trial of intrabone marrow cord blood transplantation and comparison of the hematological recovery with the Japanese nationwide database2017
Author(s)
Kurita N, Gosho M, Yokoyama Y, Kato T, Obara N, Sakata-Yanagimoto M, Hasegawa Y, Uchida N, Takahashi S, Kouzai Y, Atsuta Y, Kurata M, Ichinohe T, Chiba S
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Journal Title
Bone Marrow Transplantation
Volume: 52
Issue: 4
Pages: 574-579
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Improved Platelet Recovery after Intra-Bone Marrow Cord Blood Transplantation: a Result of Phase I/II Trial and a Comparison with Japanese Nation-Wide Transplant Database2016
Author(s)
Naoki Kurita, Masahiko Gosho, Yasuhisa Yokoyama, Hideharu Muto, Takayasu Kato, Mamiko Sakata-Yanagimoto, Naoshi Obara, Yuichi Hasegawa, Yoshiko Atsuta, Tatsuo Ichinohe, Francesco Frassoni, Shigeru Chiba
Organizer
The 7th JSH International Symposium 2016
Place of Presentation
淡路夢舞台国際会議場(兵庫県淡路市)
Year and Date
2016-05-13
Related Report
Int'l Joint Research