| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we aimed to identify novel lipid mediators which might be associated with inflammation in model mice for collagen vascular diseases. We measured lipid mediators in MRL/lpr mice (lupus model mice) and MRL/MpJ mice (wild type mice) using LC-MS and revealed that PEA and OEA levels were decreased in serum and spleen in MRL/lpr mice compared to MRL/MpJ mice. PEA and OEA inhibited TLR9-mediated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells and B cells in vitro. Moreover, PEA and OEA reduced IL-6 production in mice injected with CpG and D-galactosamine. Further researches are needed to clarify whether PEA and OEA could be potential therapeutic candidates to modulate inflammation in SLE.
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