Identification of new lipid mediators associated with inflammation in model mice for collagen vascular diseases
| Project/Area Number |
15K19577
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Oita University |
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Principal Investigator |
Ozaki Takashi 大分大学, 医学部, 病院特任助教 (70749374)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脂質メディエーター / SLE / パルミトイルエタノールアミド / オレオイルエタノールアミド / 炎症性サイトカイン / Toll様受容体9 / LC-MS / 膠原病 / 炎症 / 樹状細胞 / Toll様受容体 / TRAF6 |
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| Outline of Final Research Achievements |
In this study, we aimed to identify novel lipid mediators which might be associated with inflammation in model mice for collagen vascular diseases. We measured lipid mediators in MRL/lpr mice (lupus model mice) and MRL/MpJ mice (wild type mice) using LC-MS and revealed that PEA and OEA levels were decreased in serum and spleen in MRL/lpr mice compared to MRL/MpJ mice. PEA and OEA inhibited TLR9-mediated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells and B cells in vitro. Moreover, PEA and OEA reduced IL-6 production in mice injected with CpG and D-galactosamine. Further researches are needed to clarify whether PEA and OEA could be potential therapeutic candidates to modulate inflammation in SLE.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Ribavirin inhibits Zika virus (ZIKV) replication inハvitro and suppresses viremia in ZIKV- infected STAT1-deficient mice.2017
Author(s)
Kamiyama N, Soma R, Hidano S, Watanabe K, Umekita H, Fukuda C, Noguchi K, Gendo Y, Ozaki T, Sonoda A, Sachi N, Runtuwene LR, Miura Y, Matsubara E, Tajima S, Takasaki T, Eshita Y, Kobayashi T.
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Journal Title
Antiviral Res.
Volume: 146
Pages: 1-11
DOI
Related Report
Peer Reviewed
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[Presentation] Inhibition of TLR9-induced dendritic cell activation and pro-inflammatory cytokine production by Oleoylethanolamide, whose level is reduced in MRL/lpr mice2017
Author(s)
尾崎貴士, 園田光, 玄同淑子, 野口香緒里, 佐知望美, 神山長慶 , 飛彈野真也 , 石井宏治 , 柴田洋孝 , 小林隆志
Organizer
2017年度生命科学系学会合同年次大会
Related Report
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[Presentation] 新規脂質メディエーターのOEA及びPEAは、Toll様受容体9(TLR9)刺激による樹状細胞とB細胞の活性化を抑制する2017
Author(s)
尾崎貴士, 後藤亮, 園田光, 広瀬晴奈, 玄同淑子 , 野口香緒里, 神山長慶 , 飛彈野真也 , 石井宏治 , 柴田洋孝 , 小林隆志
Organizer
第8回 癌・炎症と抗酸化研究会(CIA研究会)
Related Report
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[Presentation] Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice2017
Author(s)
神山長慶, 相馬颯介, 飛彈野真也, Benjawan Saechue, 佐知望美, 野口香緒里, 尾崎貴士, 園田光, 玄同淑子, 江下優樹, 小林隆志
Organizer
2017年度生命科学系学会合同年次大会
Related Report
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