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Mechanisms of bone-healing in rheumatoid arthritis using NaF-PET

Research Project

Project/Area Number 15K19578
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionYokohama City University

Principal Investigator

Minegishi Kaoru  横浜市立大学, 附属市民総合医療センター, 助教 (40616877)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨修復 / NaF-PET / 骨破壊 / 関節リウマチ / 骨代謝
Outline of Final Research Achievements

We assessed rheumatoid arthritis (RA) patients using FDG-PET and NaF-PET/CT. NaF and FDG signals were mainly located in the bone and the surrounding soft tissues, respectively. Co-existing PET signals of FDG and NaF in the affected joints suggest that inflammation is coupled with upregulated bone turnover, leading to joint destruction. Furthermore, bone repair was more frequently occurred in early-stage RA patients who have achieved sustained good clinical response.
On the other hand, reducing inflammation and bone destraction by heme oxygenase 1 (HO-1) induction was shown in Bach1-deficient mice of collagen-induced arthritis model. Inhibition of Bach1 activity may be worthy of consideration as a target for treatment of inflammatory bone loss in RA.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Diagnostic test accuracy of ultrasound for synovitis in rheumatoid arthritis: systematic review and meta-analysis.2017

    • Author(s)
      Takase-Minegishi K, Horita N, Kobayashi K, Yoshimi R, Kirino Y, Ohno S, Kaneko T, Nakajima H, Wakefield RJ, Emery P.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 印刷中 Issue: 1 Pages: 49-58

    • DOI

      10.1093/rheumatology/kex036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] (18)F-FDG and (18)F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis2016

    • Author(s)
      Watanabe T, Takase-Minegishi K, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Hama M, Yoshimi R, Kirino Y, Asami Y, Suda A, Ohno S, Tateishi U, Ueda A, Takeno M, Ishigatsubo Y
    • Journal Title

      Mod Rheumatol

      Volume: 26 Issue: 2 Pages: 180-187

    • DOI

      10.3109/14397595.2015.1069458

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Diagnostic test accuracy of ultrasonography for synovitis in rheumatoid arthritis: systematic review and meta-analysis.2017

    • Author(s)
      Minegishi K, Horita N, Kobaashi K, Yoshimi R, Kirino Y, Ohno S, Nakajima H
    • Organizer
      The 61st Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Repair of bone erosions in rheumatoid arthritis patients treated with the first biological disease-modifying antirheumatic drugs.2016

    • Author(s)
      1.Minegishi K, Toyota Y, Tsuchida N, Sugiyama Y, Kishimoto D, Kamiyama R, Tamura M, Yoshimi R, Kirino Y, Takeno M, Ishigatsubo Y, Ohno S, Ueda A.
    • Organizer
      The 60th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology
    • Place of Presentation
      横浜
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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