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Revival use of existing antibiotics for antimicrobial resistant organisms

Research Project

Project/Area Number 15K19585
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionOsaka University

Principal Investigator

Hagiya Hideharu  大阪大学, 医学部附属病院, 助教 (30718531)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsカルバペネム耐性腸内細菌科細菌 / セファマイシン / セフメタゾール / メロペネム / 併用療法 / NDM / IMP / KPC / 薬剤耐性菌 / リバイバル / ラタモキセフ / ホスホマイシン / カルバペネム
Outline of Final Research Achievements

Antimicrobial resistance, especially carbapenemase-producing Enterobacteriaceae (CPE), is an ongoing problem that globally undermines medical settings. Considering the high cost of developing new classes of antibiotics, “revival use” of existing antimicrobial agents provides another option to combat the highly resistant microorganisms. In this study, we assessed in vitro efficacy of combination therapy with meropenem and cefmetazole against various carbapenemase-producing Enterobacteriaceae. We applied standard checkerboard and time-kill assays, and revealed a therapeutic possibility of this new combination therapy. Further research on the pharmacokinetic and pharmacodynamics utility, as well as optimal therapeutic regimen and clinical outcomes, should be warranted.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Clinical ineffectiveness of latamoxef for Stenotrophomonas maltophilia infection2015

    • Author(s)
      Hideharu Hagiya, et al
    • Journal Title

      Infection and Drug Resistant

      Volume: 8 Pages: 353-357

    • DOI

      10.2147/idr.s90726

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] In Vitro Efficacy of Combination Therapy with Meropenem and Cefmetazole against KPC-producing Enterobacteriaceae2017

    • Author(s)
      Hideharu Hagiya
    • Organizer
      the ASM Microbe 2017
    • Place of Presentation
      米国(ニューオーリンズ)
    • Year and Date
      2017-06-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro efficacy of meropenem-cefmetazole combination therapy against NDM-producing Escherichia coli2017

    • Author(s)
      Hidhearu Hagiya
    • Organizer
      the 27th European Congress of Clinical Microbiology and Infectious Diseases
    • Place of Presentation
      オーストリア(ウィーン)
    • Year and Date
      2017-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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